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- W3153973544 abstract "During embryo development, tissues often undergo multiple concomitant changes in shape. It is unclear which signaling pathways and cellular mechanisms are responsible for multiple simultaneous tissue shape transformations. We focus on the process of concomitant tissue folding and extension that is key during gastrulation and neurulation. We use the Drosophila embryo as model system and focus on the process of mesoderm invagination. Here, we show that the prospective mesoderm simultaneously folds and extends. We report that mesoderm cells, under the control of anterior-posterior and dorsal-ventral gene patterning synergy, establish two sets of adherens junctions at different apical-basal positions with specialized functions: while apical junctions drive apical constriction initiating tissue bending, lateral junctions concomitantly drive polarized cell intercalation, resulting in tissue convergence-extension. Thus, epithelial cells devise multiple specialized junctional sets that drive composite morphogenetic processes under the synergistic control of apparently orthogonal signaling sources." @default.
- W3153973544 created "2021-04-26" @default.
- W3153973544 creator A5009980186 @default.
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- W3153973544 date "2021-05-01" @default.
- W3153973544 modified "2023-10-03" @default.
- W3153973544 title "A two-tier junctional mechanism drives simultaneous tissue folding and extension" @default.
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- W3153973544 doi "https://doi.org/10.1016/j.devcel.2021.04.003" @default.
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