FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3154016670> ?p ?o ?g. }

• W3154016670 abstract "Alzheimer’s disease (AD) is one of the most frequently diagnosed neurodegenerative disorders worldwide and poses a major challenge for both affected individuals and their caregivers. AD is a progressive neurological disorder associated with high rates of brain atrophy. Despite its durable influence on human health, understanding AD has been complicated by its enigmatic and multifactorial nature. Neurofibrillary tangles and the deposition of amyloid-beta (Aβ) protein are typical pathological features and fundamental causes of cognitive impairment in AD patients. Dysbiosis of oral and gut microbiota has been reported to induce and accelerate the formation of Aβ plaques and neurofibrillary tangles. For instance, some oral microbes can spread to the brain through cranial nerves or cellular infections, which has been suggested to increase the risk of developing AD. Importantly, the interaction between intestinal microbiota and brain cells has been recognized as influencing the development of AD as well as other neurodegenerative diseases. In particular, the metabolites produced by certain intestinal microorganisms can affect the activity of microglia and further mediate neuroinflammation, which is a leading cause of neuronal necrosis and AD pathogenesis. Which pathogens and associated pathways are involved in the development and progression of AD remains to be elucidated; however, it is well-known that gut microbiota and their metabolites can affect the brain by both direct and indirect means. Understanding the specific mechanisms involved in the interaction between these pathogens and the nervous system is vital for the early intervention in AD. In this review, we aim to comprehensively discuss the possible mechanistic pathways underlying the oral-brain, the gut-brain and the oral-gut-brain associations." @default.
• W3154016670 created "2021-04-26" @default.
• W3154016670 creator A5019123034 @default.
• W3154016670 creator A5048869783 @default.
• W3154016670 creator A5056183538 @default.
• W3154016670 creator A5068392270 @default.
• W3154016670 creator A5070669879 @default.
• W3154016670 creator A5072441339 @default.
• W3154016670 date "2021-04-14" @default.
• W3154016670 modified "2023-10-14" @default.
• W3154016670 title "The Oral-Gut-Brain AXIS: The Influence of Microbes in Alzheimer’s Disease" @default.
• W3154016670 cites W1508289240 @default.
• W3154016670 cites W1514623095 @default.
• W3154016670 cites W1520284233 @default.
• W3154016670 cites W1536799771 @default.
• W3154016670 cites W1841772591 @default.
• W3154016670 cites W1966337931 @default.
• W3154016670 cites W1977428675 @default.
• W3154016670 cites W1979495039 @default.
• W3154016670 cites W1980475824 @default.
• W3154016670 cites W1989889776 @default.
• W3154016670 cites W2012283043 @default.
• W3154016670 cites W2015567271 @default.
• W3154016670 cites W2016271868 @default.
• W3154016670 cites W2019271691 @default.
• W3154016670 cites W2029943794 @default.
• W3154016670 cites W2039069312 @default.
• W3154016670 cites W2045264957 @default.
• W3154016670 cites W2047798386 @default.
• W3154016670 cites W2048830729 @default.
• W3154016670 cites W2052286291 @default.
• W3154016670 cites W2055010339 @default.
• W3154016670 cites W2057031142 @default.
• W3154016670 cites W2058352213 @default.
• W3154016670 cites W2062506676 @default.
• W3154016670 cites W2064410624 @default.
• W3154016670 cites W2069893872 @default.
• W3154016670 cites W2074454132 @default.
• W3154016670 cites W2076828736 @default.
• W3154016670 cites W2087243986 @default.
• W3154016670 cites W2087966568 @default.
• W3154016670 cites W2094777896 @default.
• W3154016670 cites W2096837196 @default.
• W3154016670 cites W2099157718 @default.
• W3154016670 cites W2100542863 @default.
• W3154016670 cites W2101918654 @default.
• W3154016670 cites W2112890441 @default.
• W3154016670 cites W2114738387 @default.
• W3154016670 cites W2122291074 @default.
• W3154016670 cites W2142486529 @default.
• W3154016670 cites W2150345049 @default.
• W3154016670 cites W2161632831 @default.
• W3154016670 cites W2162149255 @default.
• W3154016670 cites W2164342861 @default.
• W3154016670 cites W2164386968 @default.
• W3154016670 cites W2166691283 @default.
• W3154016670 cites W2217972398 @default.
• W3154016670 cites W2295588523 @default.
• W3154016670 cites W2484000749 @default.
• W3154016670 cites W2508213551 @default.
• W3154016670 cites W2514426295 @default.
• W3154016670 cites W2519408637 @default.
• W3154016670 cites W2545292312 @default.
• W3154016670 cites W2548957578 @default.
• W3154016670 cites W2559475643 @default.
• W3154016670 cites W2621695716 @default.
• W3154016670 cites W2735753950 @default.
• W3154016670 cites W2737142452 @default.
• W3154016670 cites W2753844903 @default.
• W3154016670 cites W2758170246 @default.
• W3154016670 cites W2761210275 @default.
• W3154016670 cites W2763573995 @default.
• W3154016670 cites W2769932220 @default.
• W3154016670 cites W2777995939 @default.
• W3154016670 cites W2789006532 @default.
• W3154016670 cites W2799631956 @default.
• W3154016670 cites W2801072950 @default.
• W3154016670 cites W2807772034 @default.
• W3154016670 cites W2890670389 @default.
• W3154016670 cites W2895374072 @default.
• W3154016670 cites W2896204288 @default.
• W3154016670 cites W2897037806 @default.
• W3154016670 cites W2897474242 @default.
• W3154016670 cites W2897533172 @default.
• W3154016670 cites W2912555658 @default.
• W3154016670 cites W2913388430 @default.
• W3154016670 cites W2945327298 @default.
• W3154016670 cites W2947686928 @default.
• W3154016670 cites W2954197440 @default.
• W3154016670 cites W2972007077 @default.
• W3154016670 cites W2977384141 @default.
• W3154016670 cites W2995308649 @default.
• W3154016670 cites W3027658010 @default.
• W3154016670 cites W3028510388 @default.
• W3154016670 cites W3039498094 @default.
• W3154016670 cites W3045169544 @default.
• W3154016670 cites W3083830205 @default.
• W3154016670 cites W3093425074 @default.
• W3154016670 cites W3103133353 @default.
• W3154016670 cites W4211216239 @default.

• next