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- W3154017310 endingPage "4134" @default.
- W3154017310 startingPage "4134" @default.
- W3154017310 abstract "DNA double-strand breaks (DSBs) are accidental lesions generated by various endogenous or exogenous stresses. DSBs are also genetically programmed events during the V(D)J recombination process, meiosis, or other genome rearrangements, and they are intentionally generated to kill cancer during chemo- and radiotherapy. Most DSBs are processed in mammalian cells by the classical nonhomologous end-joining (c-NHEJ) pathway. Understanding the molecular basis of c-NHEJ has major outcomes in several fields, including radiobiology, cancer therapy, immune disease, and genome editing. The heterodimer Ku70/80 (Ku) is a central actor of the c-NHEJ as it rapidly recognizes broken DNA ends in the cell and protects them from nuclease activity. It subsequently recruits many c-NHEJ effectors, including nucleases, polymerases, and the DNA ligase 4 complex. Beyond its DNA repair function, Ku is also involved in several other DNA metabolism processes. Here, we review the structural and functional data on the DNA and RNA recognition properties of Ku implicated in DNA repair and in telomeres maintenance." @default.
- W3154017310 created "2021-04-26" @default.
- W3154017310 creator A5005044986 @default.
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- W3154017310 creator A5048588313 @default.
- W3154017310 creator A5056164519 @default.
- W3154017310 creator A5068530374 @default.
- W3154017310 date "2021-04-16" @default.
- W3154017310 modified "2023-10-15" @default.
- W3154017310 title "The Multifaceted Roles of Ku70/80" @default.
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