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- W3154061227 abstract "BACKGROUND: It is difficult to properly compare the different treatment modalities for basal cell carcinoma (BCC) due to a lack of standardization in outcome reporting in clinical studies. Examining the range of reported outcomes can help clarify the need to have a standardized set of outcomes to be measured at minimum in future clinical studies. OBJECTIVE: To identify outcomes that have been reported in clinical studies of BCC treatments. METHODS: A systematic review was performed for English-language human studies of basal cell carcinoma treatments conducted between January 1980 and July 2016. Prospective studies that reported at least one clinical outcome were included for review. Outcomes were then categorized into domains based on shared similarities. RESULTS: 70 studies were included, and 235 outcomes were identified and grouped into 8 domains: clinical assessment; safety and tolerability of treatment; treatment effectiveness; recurrence, progression, and remission; histologic assessment; procedural factors; pharmacokinetic considerations; and patient satisfaction. The most commonly reported outcome was “adverse events” (reported in 22 of 70 studies, 31.4%). Other common outcomes were “overall cosmetic/aesthetic outcome” (10 articles; 14.3%), and “incidence of new BCCs” (9 articles; 12.9%). CONCLUSIONS: There exists wide variability in the outcomes used to measure treatment success for BCC, and there is a need to have a standardized set of outcomes that are reported in BCC studies." @default.
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- W3154061227 date "2021-05-01" @default.
- W3154061227 modified "2023-10-17" @default.
- W3154061227 title "457 Outcomes reported in clinical trials of basal cell carcinoma: A systematic review" @default.
- W3154061227 doi "https://doi.org/10.1016/j.jid.2021.02.480" @default.
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