FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3154085013> ?p ?o ?g. }

• W3154085013 endingPage "1741" @default.
• W3154085013 startingPage "1741" @default.
• W3154085013 abstract "High-grade Gastroenteropancreatic Neuroendocrine neoplasms (H-NENs) comprehend well-differentiated tumors (NET G3) and poorly differentiated carcinomas (NEC) with proliferative activity indexes as mitotic count (MC) >20 mitoses/10 HPF and Ki-67 >20%. At present, no specific therapy for H-NENs exists and the several evidences of microenvironment involvement in their pathogenesis pave the way for tailored therapies. Forty-five consecutive cases, with available information about T-cell, immune, and non-immune markers, from surgical pathology and clinical databases of 2 Italian institutions were immunostained for Arginase, CD33, CD163 and CD66 myeloid markers. The association between features was assessed by Spearman’s correlation coefficient. A unsupervised K-means algorithm was used to identify clusters of patients according to inputs of microenvironment features and the relationship between clusters and clinicopathological features, including cancer-specific survival (CSS), was analyzed. The H-NEN population was composed of 6 (13.3%) NET G3 and 39 (86.7%) NEC. Overall, significant positive associations were found between myeloid (CD33, CD163 and Arginase) and T/immune markers (CD3, CD4, CD8, PD-1 and HLA-I). Myeloid and T-cell markers CD3 and CD8 identified two clusters of patients from unsupervised K-means analysis. Cases grouped in cluster 1 with more myeloid infiltrates, T cell, HLA and expression of inhibitory receptors and ligands in the stroma (PD-1, PD-L1) had significantly better CSS than patients in cluster 2. Multivariable analysis showed that Ki-67 (>55 vs. <55, HR 8.60, CI 95% 2.61–28.33, p < 0.0001) and cluster (1 vs. 2, HR 0.43, CI 95% 0.20–0.93, p = 0.03) were significantly associated with survival. High grade gastroenteropancreatic neuroendocrine neoplasms can be further classified into two prognostic sub-populations of tumors driven by different tumor microenvironments and immune features able to generate the framework for evaluating new therapeutic strategies." @default.
• W3154085013 created "2021-04-26" @default.
• W3154085013 creator A5001956192 @default.
• W3154085013 creator A5003507376 @default.
• W3154085013 creator A5005310931 @default.
• W3154085013 creator A5008187226 @default.
• W3154085013 creator A5012522320 @default.
• W3154085013 creator A5027878979 @default.
• W3154085013 creator A5031755427 @default.
• W3154085013 creator A5033857663 @default.
• W3154085013 creator A5039670785 @default.
• W3154085013 creator A5040221244 @default.
• W3154085013 creator A5040559926 @default.
• W3154085013 creator A5053845233 @default.
• W3154085013 creator A5060352190 @default.
• W3154085013 creator A5062125611 @default.
• W3154085013 creator A5065963603 @default.
• W3154085013 creator A5083310604 @default.
• W3154085013 creator A5086755697 @default.
• W3154085013 creator A5088581133 @default.
• W3154085013 creator A5091777805 @default.
• W3154085013 date "2021-04-17" @default.
• W3154085013 modified "2023-09-27" @default.
• W3154085013 title "Myeloid and T-Cell Microenvironment Immune Features Identify Two Prognostic Sub-Groups in High-Grade Gastroenteropancreatic Neuroendocrine Neoplasms" @default.
• W3154085013 cites W1977556410 @default.
• W3154085013 cites W1992615452 @default.
• W3154085013 cites W2004150448 @default.
• W3154085013 cites W2082118645 @default.
• W3154085013 cites W2087690546 @default.
• W3154085013 cites W2117692326 @default.
• W3154085013 cites W2122403898 @default.
• W3154085013 cites W2227093581 @default.
• W3154085013 cites W2290138226 @default.
• W3154085013 cites W2535295725 @default.
• W3154085013 cites W2555275271 @default.
• W3154085013 cites W2559084845 @default.
• W3154085013 cites W2568946517 @default.
• W3154085013 cites W2591628935 @default.
• W3154085013 cites W2776930747 @default.
• W3154085013 cites W2782949806 @default.
• W3154085013 cites W2796207838 @default.
• W3154085013 cites W2889329929 @default.
• W3154085013 cites W2889371124 @default.
• W3154085013 cites W2889934166 @default.
• W3154085013 cites W2915008682 @default.
• W3154085013 cites W2948015593 @default.
• W3154085013 cites W2969395385 @default.
• W3154085013 cites W2969542839 @default.
• W3154085013 cites W3012519247 @default.
• W3154085013 cites W3013205517 @default.
• W3154085013 cites W3031843204 @default.
• W3154085013 cites W3038480745 @default.
• W3154085013 cites W3064023541 @default.
• W3154085013 cites W3091678046 @default.
• W3154085013 cites W3112719092 @default.
• W3154085013 cites W3124686987 @default.
• W3154085013 doi "https://doi.org/10.3390/jcm10081741" @default.
• W3154085013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8072982" @default.
• W3154085013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33920514" @default.
• W3154085013 hasPublicationYear "2021" @default.
• W3154085013 type Work @default.
• W3154085013 sameAs 3154085013 @default.
• W3154085013 citedByCount "4" @default.
• W3154085013 countsByYear W31540850132021 @default.
• W3154085013 countsByYear W31540850132022 @default.
• W3154085013 crossrefType "journal-article" @default.
• W3154085013 hasAuthorship W3154085013A5001956192 @default.
• W3154085013 hasAuthorship W3154085013A5003507376 @default.
• W3154085013 hasAuthorship W3154085013A5005310931 @default.
• W3154085013 hasAuthorship W3154085013A5008187226 @default.
• W3154085013 hasAuthorship W3154085013A5012522320 @default.
• W3154085013 hasAuthorship W3154085013A5027878979 @default.
• W3154085013 hasAuthorship W3154085013A5031755427 @default.
• W3154085013 hasAuthorship W3154085013A5033857663 @default.
• W3154085013 hasAuthorship W3154085013A5039670785 @default.
• W3154085013 hasAuthorship W3154085013A5040221244 @default.
• W3154085013 hasAuthorship W3154085013A5040559926 @default.
• W3154085013 hasAuthorship W3154085013A5053845233 @default.
• W3154085013 hasAuthorship W3154085013A5060352190 @default.
• W3154085013 hasAuthorship W3154085013A5062125611 @default.
• W3154085013 hasAuthorship W3154085013A5065963603 @default.
• W3154085013 hasAuthorship W3154085013A5083310604 @default.
• W3154085013 hasAuthorship W3154085013A5086755697 @default.
• W3154085013 hasAuthorship W3154085013A5088581133 @default.
• W3154085013 hasAuthorship W3154085013A5091777805 @default.
• W3154085013 hasBestOaLocation W31540850131 @default.
• W3154085013 hasConcept C10205521 @default.
• W3154085013 hasConcept C104317684 @default.
• W3154085013 hasConcept C126322002 @default.
• W3154085013 hasConcept C127716648 @default.
• W3154085013 hasConcept C143998085 @default.
• W3154085013 hasConcept C1491633281 @default.
• W3154085013 hasConcept C167672396 @default.
• W3154085013 hasConcept C176290653 @default.
• W3154085013 hasConcept C203014093 @default.
• W3154085013 hasConcept C2775858924 @default.
• W3154085013 hasConcept C2776051438 @default.
• W3154085013 hasConcept C2776107976 @default.

• next