Matches in SemOpenAlex for { <https://semopenalex.org/work/W3154091431> ?p ?o ?g. }
- W3154091431 abstract "Abstract The use of exosomes in clinical settings is progressively becoming a reality, as clinical trials testing exosomes for diagnostic and therapeutic applications are generating remarkable interest from the scientific community and investors. Exosomes are small extracellular vesicles secreted by all cell types playing intercellular communication roles in health and disease by transferring cellular cargoes such as functional proteins, metabolites and nucleic acids to recipient cells. An in-depth understanding of exosome biology is therefore essential to ensure clinical development of exosome based investigational therapeutic products. Here we summarise the most up-to-date knowkedge about the complex biological journey of exosomes from biogenesis and secretion, transport and uptake to their intracellular signalling. We delineate the major pathways and molecular players that influence each step of exosome physiology, highlighting the routes of interest, which will be of benefit to exosome manipulation and engineering. We highlight the main controversies in the field of exosome research: their adequate definition, characterisation and biogenesis at plasma membrane. We also delineate the most common identified pitfalls affecting exosome research and development. Unravelling exosome physiology is key to their ultimate progression towards clinical applications." @default.
- W3154091431 created "2021-04-26" @default.
- W3154091431 creator A5020800689 @default.
- W3154091431 creator A5025727534 @default.
- W3154091431 creator A5053691264 @default.
- W3154091431 creator A5075623849 @default.
- W3154091431 date "2021-04-23" @default.
- W3154091431 modified "2023-10-18" @default.
- W3154091431 title "The exosome journey: from biogenesis to uptake and intracellular signalling" @default.
- W3154091431 cites W1526830066 @default.
- W3154091431 cites W1553296079 @default.
- W3154091431 cites W1572155486 @default.
- W3154091431 cites W1835592430 @default.
- W3154091431 cites W1859042441 @default.
- W3154091431 cites W1915536483 @default.
- W3154091431 cites W1950118853 @default.
- W3154091431 cites W1963747091 @default.
- W3154091431 cites W1964632582 @default.
- W3154091431 cites W1967086605 @default.
- W3154091431 cites W1967367827 @default.
- W3154091431 cites W1969123951 @default.
- W3154091431 cites W1969690132 @default.
- W3154091431 cites W1969722884 @default.
- W3154091431 cites W1970870994 @default.
- W3154091431 cites W1971171177 @default.
- W3154091431 cites W1973895646 @default.
- W3154091431 cites W1974954833 @default.
- W3154091431 cites W1979751563 @default.
- W3154091431 cites W1986820887 @default.
- W3154091431 cites W1989274589 @default.
- W3154091431 cites W1989603382 @default.
- W3154091431 cites W1993140699 @default.
- W3154091431 cites W1996997447 @default.
- W3154091431 cites W1997839825 @default.
- W3154091431 cites W1998284209 @default.
- W3154091431 cites W1998416648 @default.
- W3154091431 cites W2001525415 @default.
- W3154091431 cites W2002498072 @default.
- W3154091431 cites W2003343932 @default.
- W3154091431 cites W2007764474 @default.
- W3154091431 cites W2008757142 @default.
- W3154091431 cites W2009896070 @default.
- W3154091431 cites W2014855123 @default.
- W3154091431 cites W2015312036 @default.
- W3154091431 cites W2015994724 @default.
- W3154091431 cites W2020432242 @default.
- W3154091431 cites W2020498762 @default.
- W3154091431 cites W2021260035 @default.
- W3154091431 cites W2025122518 @default.
- W3154091431 cites W2027167191 @default.
- W3154091431 cites W2028248159 @default.
- W3154091431 cites W2032945008 @default.
- W3154091431 cites W2035861820 @default.
- W3154091431 cites W2036073789 @default.
- W3154091431 cites W2038236600 @default.
- W3154091431 cites W2038634187 @default.
- W3154091431 cites W2039313867 @default.
- W3154091431 cites W2040481506 @default.
- W3154091431 cites W2045017588 @default.
- W3154091431 cites W2046133662 @default.
- W3154091431 cites W2046369033 @default.
- W3154091431 cites W2049074403 @default.
- W3154091431 cites W2051688548 @default.
- W3154091431 cites W2054077259 @default.
- W3154091431 cites W2055155951 @default.
- W3154091431 cites W2055313665 @default.
- W3154091431 cites W2058056641 @default.
- W3154091431 cites W2062984171 @default.
- W3154091431 cites W2064552877 @default.
- W3154091431 cites W2066234893 @default.
- W3154091431 cites W2066843867 @default.
- W3154091431 cites W2067775919 @default.
- W3154091431 cites W2069818169 @default.
- W3154091431 cites W2070709903 @default.
- W3154091431 cites W2072109464 @default.
- W3154091431 cites W2072167135 @default.
- W3154091431 cites W2073341747 @default.
- W3154091431 cites W2080418767 @default.
- W3154091431 cites W2083757415 @default.
- W3154091431 cites W2086612059 @default.
- W3154091431 cites W2090892913 @default.
- W3154091431 cites W2091250479 @default.
- W3154091431 cites W2096794442 @default.
- W3154091431 cites W2098148530 @default.
- W3154091431 cites W2098259366 @default.
- W3154091431 cites W2099491642 @default.
- W3154091431 cites W2105726520 @default.
- W3154091431 cites W2109854904 @default.
- W3154091431 cites W2109934828 @default.
- W3154091431 cites W2110683593 @default.
- W3154091431 cites W2111560326 @default.
- W3154091431 cites W2116268000 @default.
- W3154091431 cites W2119043140 @default.
- W3154091431 cites W2119764013 @default.
- W3154091431 cites W2120920292 @default.
- W3154091431 cites W2121354606 @default.
- W3154091431 cites W2121666727 @default.
- W3154091431 cites W2124304994 @default.
- W3154091431 cites W2125153740 @default.
- W3154091431 cites W2126210405 @default.