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- W3154118891 abstract "The aim of thisresearch is to modify and characterize the surface of soft materials. Firstly,the surface morphology and physical attributes of biocompatible hydrogel aretailored at micro/nano scale for biomedical research. Utilizing gallium ionbeam, thin film of hydrogel is irradiated with varied ion fluence, acceleratingvoltage and incident angle. The sputtering yield, surface morphology andmechanical properties of hydrogel film were investigated using ScanningElectron Microscopy (SEM) and Atomic Force Microscopy (AFM). The change insurface roughness, porosity and Young’s modulus (E) after the low kV ion beamirradiation was observed from nanoscale characterization of hydrogel with AFM.Furthermore, cell culture studies confirmed the biocompatibility of hydrogelafter the irradiation. In the second phase of the research, AFM spectroscopywas utilized to investigate the physiochemical properties of tissues, aiming toidentify and differentiate cell types. Young’s moduli were acquired with AFMforce spectroscopy of each cell type and chemical characterization on thesamples were also performed using the functionalized AFM tips. From the AFMspectroscopy, distinct distribution of stiffness and adhesion forces wereobserved among different cell types. Change in the surface stiffness andadhesion after ion beam ablation was also observed. The identification ofunknown cell types was performed utilizing the Kolmogorov-Smirnov (K-S) test.Finally, novel approaches of rapid fabrication of metallic nanoparticles areproposed, for functionalizing soft surfaces, with both nanostencil method andFIB direct pattering method. FIB was utilized to fabricate predesigned nanoholes on silicon nitride membrane and metallic nanoparticles were deposited onvarious surface using electron beam (E-beam) evaporator. Direct FIB etching ongold coated substrate was also performed. Both approaches were capable offabricating sub-100 nm nanoparticles with predefined parameters such asdiameter, height and spacing. The fidelity of the fabricated nanoparticles withthe original design was confirmed from AFM and SEM images. The potentialfunctionality of the nanoparticles was confirmed by investigating the nanoparticleswith angle-resolved Cathodoluminescence (CL) nanoscopy. The proposed approachcould offer advantages on various biomedical and bioengineering applications." @default.
- W3154118891 created "2021-04-26" @default.
- W3154118891 creator A5003198119 @default.
- W3154118891 date "2017-11-14" @default.
- W3154118891 modified "2023-09-27" @default.
- W3154118891 title "Nanoscale characterization and modification of soft surface" @default.
- W3154118891 doi "https://doi.org/10.4225/03/5a0a60944cdfe" @default.
- W3154118891 hasPublicationYear "2017" @default.
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