FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3154145281> ?p ?o ?g. }

• W3154145281 abstract "Abstract In view of the complicated pathophysiological process of vascular dementia (VD), drugs for the clinical treatment of VD mainly target related risk factors, while drugs with excellent efficacy in cognitive function are still relatively lacking. Imperatorin (IMP), an active constituent extracted from angelica dahuricae and notopterygium Notopterygii, which has anti-inflammatory, vasodilator, anticoagulant, block calcium channel, anticonvulsant, and anti oxygen free radical injury properties. Therefore,the present study examined its effects on VD rats and the underlying molecular mechanisms, in order to provide promising therapeutic methods. VD was established by modified ligation of perpetual two-vessel occlusion (2VO). After 2VO surgery, IMP (2.5, 5, and 10 mg/kg) was administered by intraperitoneal injection for 12 consecutive weeks to evaluate therapeutic effects. Cognitive function was verified by the Morris water maze. The neuronal morphological changes were examined via Hematoxylin–Eosin staining. Real-Time PCR and Western blot were used for detecting pro- and antiapoptotic biomarkers, and the hippocampus synaptic damage was examined by Transmission electron microscope. We revealed that 2VO-induced cognitive impairment, hippocampus CA1 neuron damage, apoptosis and synaptic damage. IMP-treatment significantly improved 2VO-induced cognitive deficits and hippocampus neuron damage. Molecular analysis revealed that IMP inhibited apoptosis through the down regulation of Bax, Caspase-3 and upregulation of Bcl-2. Meanwhile, IMP-treatment markedly improved synaptic ultrastructure morphology, increased the SAZ length, PSD thickness and up-regulated PSD-95 expression. Collectively, our findings demonstrated that IMP was effective in the treatment of 2VO-induced VD via inhibiting apoptosis of hippocampus neurons and reducing the synaptic plasticity destroy." @default.
• W3154145281 created "2021-04-26" @default.
• W3154145281 creator A5036125074 @default.
• W3154145281 creator A5039570310 @default.
• W3154145281 creator A5046632194 @default.
• W3154145281 creator A5049848118 @default.
• W3154145281 creator A5067708304 @default.
• W3154145281 creator A5073861665 @default.
• W3154145281 creator A5074100340 @default.
• W3154145281 creator A5074771978 @default.
• W3154145281 creator A5077160098 @default.
• W3154145281 date "2021-04-21" @default.
• W3154145281 modified "2023-10-07" @default.
• W3154145281 title "Effects of imperatorin on apoptosis and synaptic plasticity in vascular dementia rats" @default.
• W3154145281 cites W1569894857 @default.
• W3154145281 cites W1575233743 @default.
• W3154145281 cites W1764708442 @default.
• W3154145281 cites W1833173427 @default.
• W3154145281 cites W1916962789 @default.
• W3154145281 cites W1966151380 @default.
• W3154145281 cites W1967763225 @default.
• W3154145281 cites W1968794427 @default.
• W3154145281 cites W1986214404 @default.
• W3154145281 cites W1988355439 @default.
• W3154145281 cites W1993904537 @default.
• W3154145281 cites W2002965952 @default.
• W3154145281 cites W2035224935 @default.
• W3154145281 cites W2049752408 @default.
• W3154145281 cites W2050981541 @default.
• W3154145281 cites W2066288306 @default.
• W3154145281 cites W2067960862 @default.
• W3154145281 cites W2070995230 @default.
• W3154145281 cites W2087167534 @default.
• W3154145281 cites W2088545066 @default.
• W3154145281 cites W2089285892 @default.
• W3154145281 cites W2091027628 @default.
• W3154145281 cites W2094731304 @default.
• W3154145281 cites W2110936582 @default.
• W3154145281 cites W2114113470 @default.
• W3154145281 cites W2118067527 @default.
• W3154145281 cites W2151454448 @default.
• W3154145281 cites W2607493369 @default.
• W3154145281 cites W2607610086 @default.
• W3154145281 cites W2767216004 @default.
• W3154145281 cites W2793799168 @default.
• W3154145281 cites W2801695253 @default.
• W3154145281 cites W2802130986 @default.
• W3154145281 cites W2903039965 @default.
• W3154145281 cites W2973388422 @default.
• W3154145281 cites W65521289 @default.
• W3154145281 doi "https://doi.org/10.1038/s41598-021-88206-7" @default.
• W3154145281 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8060272" @default.
• W3154145281 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33883654" @default.
• W3154145281 hasPublicationYear "2021" @default.
• W3154145281 type Work @default.
• W3154145281 sameAs 3154145281 @default.
• W3154145281 citedByCount "10" @default.
• W3154145281 countsByYear W31541452812021 @default.
• W3154145281 countsByYear W31541452812022 @default.
• W3154145281 countsByYear W31541452812023 @default.
• W3154145281 crossrefType "journal-article" @default.
• W3154145281 hasAuthorship W3154145281A5036125074 @default.
• W3154145281 hasAuthorship W3154145281A5039570310 @default.
• W3154145281 hasAuthorship W3154145281A5046632194 @default.
• W3154145281 hasAuthorship W3154145281A5049848118 @default.
• W3154145281 hasAuthorship W3154145281A5067708304 @default.
• W3154145281 hasAuthorship W3154145281A5073861665 @default.
• W3154145281 hasAuthorship W3154145281A5074100340 @default.
• W3154145281 hasAuthorship W3154145281A5074771978 @default.
• W3154145281 hasAuthorship W3154145281A5077160098 @default.
• W3154145281 hasBestOaLocation W31541452811 @default.
• W3154145281 hasConcept C104317684 @default.
• W3154145281 hasConcept C126322002 @default.
• W3154145281 hasConcept C142724271 @default.
• W3154145281 hasConcept C170493617 @default.
• W3154145281 hasConcept C190283241 @default.
• W3154145281 hasConcept C196795494 @default.
• W3154145281 hasConcept C204232928 @default.
• W3154145281 hasConcept C2776415932 @default.
• W3154145281 hasConcept C2777952318 @default.
• W3154145281 hasConcept C2779134260 @default.
• W3154145281 hasConcept C2779483572 @default.
• W3154145281 hasConcept C2781161787 @default.
• W3154145281 hasConcept C42219234 @default.
• W3154145281 hasConcept C44752575 @default.
• W3154145281 hasConcept C55493867 @default.
• W3154145281 hasConcept C71924100 @default.
• W3154145281 hasConcept C86803240 @default.
• W3154145281 hasConcept C98229152 @default.
• W3154145281 hasConcept C98274493 @default.
• W3154145281 hasConceptScore W3154145281C104317684 @default.
• W3154145281 hasConceptScore W3154145281C126322002 @default.
• W3154145281 hasConceptScore W3154145281C142724271 @default.
• W3154145281 hasConceptScore W3154145281C170493617 @default.
• W3154145281 hasConceptScore W3154145281C190283241 @default.
• W3154145281 hasConceptScore W3154145281C196795494 @default.
• W3154145281 hasConceptScore W3154145281C204232928 @default.
• W3154145281 hasConceptScore W3154145281C2776415932 @default.
• W3154145281 hasConceptScore W3154145281C2777952318 @default.
• W3154145281 hasConceptScore W3154145281C2779134260 @default.

• next