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• W3154190006 endingPage "107602962110089" @default.
• W3154190006 startingPage "107602962110089" @default.
• W3154190006 abstract "Hypercoagulability in coronavirus disease 2019 (COVID-19) may aggravate disease severity during hospitalization but the reported survival benefits from anticoagulation (AC) vary among studies. We performed a literature research to estimate pooled odds ratios (ORs) of in-hospital mortality and major bleeding comparing among intermediate-to-therapeutic dose AC, prophylactic dose AC, and no AC. Until October 22, 2020, PubMed, EMBASE, and Cochrane Library Database were searched for studies reporting AC utilization and mortality in COVID-19. Studies with suspected risk of bias were excluded before the synthesis of pooled ORs with 95% confidence intervals (CIs) using random-effects models. Of 37 identified studies (N = 19,510), 17 (N = 17,833) were aggregated in the meta-analysis. The overall mortality rate was 23.1% (95% CI 18.7-28.2). The pooled odds of mortality comparing anticoagulated to non-anticoagulated patients were similar, but lower in prophylactic dose AC group (OR 0.83; 95% CI 0.73-0.95). Notably, intermediate-to-therapeutic dose AC increased mortality (OR 1.60; 95% CI 1.11-2.31) and major bleeding compared to prophylactic dose AC (OR 3.33; 95% CI 2.34-4.72). Our findings support the optimal efficacy and safety profiles of prophylactic dose AC in hospitalized COVID-19 patients." @default.
• W3154190006 created "2021-04-26" @default.
• W3154190006 creator A5034085122 @default.
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• W3154190006 creator A5063514590 @default.
• W3154190006 creator A5066150656 @default.
• W3154190006 creator A5087541392 @default.
• W3154190006 date "2021-01-01" @default.
• W3154190006 modified "2023-10-05" @default.
• W3154190006 title "Anticoagulation and In-Hospital Mortality From Coronavirus Disease 2019: A Systematic Review and Meta-Analysis" @default.
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• W3154190006 doi "https://doi.org/10.1177/10760296211008999" @default.
• W3154190006 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8060743" @default.
• W3154190006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33874753" @default.
• W3154190006 hasPublicationYear "2021" @default.
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