FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3154194773> ?p ?o ?g. }

• W3154194773 endingPage "48" @default.
• W3154194773 startingPage "24" @default.
• W3154194773 abstract "Background: Hepatotoxicity was one of the major side effects associated with doxorubicin treatment in cancer chemotherapy. The synthesized silver nanoparticles (AgNPs) from natural products such as algae especially green algae is one of the favorable means to minimize the deleterious effects of the chemotherapy. Thus, this study aimed to evaluate the preventive role of AgNPs synthesized by Ulva fasciata (U. fasciata) against doxorubicin-induced hepatotoxicity and oxidative stress in the liver of male Wistar rats. &#x0D; Materials and Methods: In the present study, the green macroalga U. fasciata ethanolic extract was used as reducing agents to reduce Ag ions to Ag0. Doxorubicin-injected male Wistar rats were concomitantly treated with U. fasciata ethanolic extract and AgNPs synthesized by U. fasciata extract (AgNPs/U. fasciata) 3 times/week by oral gavage for 6 weeks.&#x0D; Results: The results showed that male Wistar rats injected with doxorubicin showed a significant increase in ALT, ALP and GGT activities and total bilirubin level as well as a reduction in the serum albumin level. The concurrent treatments of doxorubicin-injected rats with U. fasciata ethanolic extract and AgNPs/U. fasciata significantly abrogate these alterations. The altered levels of tumor biomarkers CA19.9 and AFP as well as pro-inflammatory cytokine, TNF-α, and anti-inflammatory cytokine, IL-4, in doxorubicin-injected animals were significantly ameliorated by concurrent treatment with U. fasciata and AgNPs/U. fasciata. Moreover, the elevated mRNA expression of p53 significantly decreased by treatment. In association, the doxorubicin-induced deleterious histological changes represented by severe hydropic degenerative changes, steatosis, inflammatory cell infiltration, Kupffer cell proliferation and apoptosis were remarkably improved by concurrent treatment with U. fasciata extract and AgNPs/U. fasciata which was more potent.&#x0D; Conclusion: Based on results of this study, it can be concluded that U. fasciata extract and AgNPs/U. fasciata counteracts doxorubicin-induced toxicity by suppression of inflammation, oxidative stress and apoptosis. AgNPs/U. fasciata was the most potent in improving hepatocyte integrity and liver histological architecture. &#x0D; Graphical Abstract&#x0D; &#x0D;" @default.
• W3154194773 created "2021-04-26" @default.
• W3154194773 creator A5004438458 @default.
• W3154194773 creator A5024924573 @default.
• W3154194773 creator A5053218128 @default.
• W3154194773 creator A5074811352 @default.
• W3154194773 creator A5080299963 @default.
• W3154194773 date "2021-04-16" @default.
• W3154194773 modified "2023-10-13" @default.
• W3154194773 title "The Preventive Effects and Mode of Actions of Ulva Fasciata Synthesized Silver Nanoparticles in Doxorubicin-Induced Hepatotoxicity in Wistar Rats" @default.
• W3154194773 cites W1525705765 @default.
• W3154194773 cites W1568927316 @default.
• W3154194773 cites W1596208789 @default.
• W3154194773 cites W1935912749 @default.
• W3154194773 cites W1958799982 @default.
• W3154194773 cites W1964574933 @default.
• W3154194773 cites W1970608848 @default.
• W3154194773 cites W1972502322 @default.
• W3154194773 cites W1977092947 @default.
• W3154194773 cites W1978017755 @default.
• W3154194773 cites W1980896349 @default.
• W3154194773 cites W1987618687 @default.
• W3154194773 cites W2004869810 @default.
• W3154194773 cites W2009845049 @default.
• W3154194773 cites W2023197012 @default.
• W3154194773 cites W2042156589 @default.
• W3154194773 cites W2042795875 @default.
• W3154194773 cites W2045308912 @default.
• W3154194773 cites W2053204557 @default.
• W3154194773 cites W2056842005 @default.
• W3154194773 cites W2058644993 @default.
• W3154194773 cites W2086592423 @default.
• W3154194773 cites W2099826413 @default.
• W3154194773 cites W2099992138 @default.
• W3154194773 cites W2101627486 @default.
• W3154194773 cites W2104777847 @default.
• W3154194773 cites W2122071242 @default.
• W3154194773 cites W2129109678 @default.
• W3154194773 cites W2132714700 @default.
• W3154194773 cites W2138443291 @default.
• W3154194773 cites W2145551323 @default.
• W3154194773 cites W2147001117 @default.
• W3154194773 cites W2164194500 @default.
• W3154194773 cites W2165600282 @default.
• W3154194773 cites W2169648776 @default.
• W3154194773 cites W2187338415 @default.
• W3154194773 cites W2191015665 @default.
• W3154194773 cites W2295920231 @default.
• W3154194773 cites W2572495833 @default.
• W3154194773 cites W2594299258 @default.
• W3154194773 cites W259706433 @default.
• W3154194773 cites W2738497405 @default.
• W3154194773 cites W2745218523 @default.
• W3154194773 cites W2753144933 @default.
• W3154194773 cites W2755464694 @default.
• W3154194773 cites W2792879732 @default.
• W3154194773 cites W2802375479 @default.
• W3154194773 cites W28630372 @default.
• W3154194773 cites W2996161037 @default.
• W3154194773 cites W3024676085 @default.
• W3154194773 doi "https://doi.org/10.9734/jpri/2021/v33i24a31429" @default.
• W3154194773 hasPublicationYear "2021" @default.
• W3154194773 type Work @default.
• W3154194773 sameAs 3154194773 @default.
• W3154194773 citedByCount "5" @default.
• W3154194773 countsByYear W31541947732022 @default.
• W3154194773 countsByYear W31541947732023 @default.
• W3154194773 crossrefType "journal-article" @default.
• W3154194773 hasAuthorship W3154194773A5004438458 @default.
• W3154194773 hasAuthorship W3154194773A5024924573 @default.
• W3154194773 hasAuthorship W3154194773A5053218128 @default.
• W3154194773 hasAuthorship W3154194773A5074811352 @default.
• W3154194773 hasAuthorship W3154194773A5080299963 @default.
• W3154194773 hasBestOaLocation W31541947731 @default.
• W3154194773 hasConcept C126322002 @default.
• W3154194773 hasConcept C134018914 @default.
• W3154194773 hasConcept C17991360 @default.
• W3154194773 hasConcept C185592680 @default.
• W3154194773 hasConcept C203014093 @default.
• W3154194773 hasConcept C2776151105 @default.
• W3154194773 hasConcept C2776694085 @default.
• W3154194773 hasConcept C2776914184 @default.
• W3154194773 hasConcept C2781303535 @default.
• W3154194773 hasConcept C55493867 @default.
• W3154194773 hasConcept C71924100 @default.
• W3154194773 hasConcept C86803240 @default.
• W3154194773 hasConcept C98274493 @default.
• W3154194773 hasConceptScore W3154194773C126322002 @default.
• W3154194773 hasConceptScore W3154194773C134018914 @default.
• W3154194773 hasConceptScore W3154194773C17991360 @default.
• W3154194773 hasConceptScore W3154194773C185592680 @default.
• W3154194773 hasConceptScore W3154194773C203014093 @default.
• W3154194773 hasConceptScore W3154194773C2776151105 @default.
• W3154194773 hasConceptScore W3154194773C2776694085 @default.
• W3154194773 hasConceptScore W3154194773C2776914184 @default.
• W3154194773 hasConceptScore W3154194773C2781303535 @default.
• W3154194773 hasConceptScore W3154194773C55493867 @default.
• W3154194773 hasConceptScore W3154194773C71924100 @default.

• next