FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3154201741> ?p ?o ?g. }

• W3154201741 endingPage "380" @default.
• W3154201741 startingPage "380" @default.
• W3154201741 abstract "The risk of developing epilepsy is strongly linked to peripheral inflammatory disorders in humans. High-mobility group box protein 1 (HMGB1) has the most focus for being a suspect in this scenario. The current study aimed to detect the celecoxib effect, an anti-inflammatory drug, on decreasing seizure susceptibility and organ damage in lipopolysaccharides (LPS)/pilocarpine (PILO) pretreated Wistar rats. Rats were divided into 6 groups (8 each): group 1 (control), group 2 (PILO), group 3 (PILO+LPS), group 4 (PILO+LPS+(VPA) Valproic acid), group 5 (PILO+LPS+Celecoxib), and group 6 (PILO+LPS+VPA+Celecoxib). LPS was used to induce sepsis and PILO to induce seizures. Oxidative stress markers, pro-inflammatory cytokines, and HMGB1 levels in serum and brain homogenate were evaluated. Histopathological studies were conducted on the hippocampus, liver, lung, and kidney. Treatment with celecoxib either alone or in combination with VPA significantly reduced Racine score and delays latency to generalized tonic-clonic seizures onset with a significant decrease in hippocampal levels of pro-inflammatory cytokines, oxidative stress markers, and increase in reduced glutathione. In addition, celecoxib treatment either alone or in combination with VPA suppressed HMGB1translocation into peripheral circulation more than treatment with VPA alone. Furthermore, hippocampus, liver, lung, and kidney histopathological changes were improved in contrast to other epileptic groups. Celecoxib either alone or combined with VPA has antiepileptic and multiorgan protective effects on acute seizures and inflammatory models induced by PILO with LPS. It decreased histopathological findings, oxidative, and inflammatory effects induced by VPA and LPS. This might be due to its anti-oxidative, anti-inflammatory and anti-HMGB1 mediated effects." @default.
• W3154201741 created "2021-04-26" @default.
• W3154201741 creator A5027004265 @default.
• W3154201741 creator A5034387560 @default.
• W3154201741 creator A5040342258 @default.
• W3154201741 creator A5066324893 @default.
• W3154201741 date "2021-04-19" @default.
• W3154201741 modified "2023-10-14" @default.
• W3154201741 title "Celecoxib Decrease Seizures Susceptibility in a Rat Model of Inflammation by Inhibiting HMGB1 Translocation" @default.
• W3154201741 cites W1536883138 @default.
• W3154201741 cites W1776233564 @default.
• W3154201741 cites W1978523851 @default.
• W3154201741 cites W1999006381 @default.
• W3154201741 cites W1999855651 @default.
• W3154201741 cites W2012803552 @default.
• W3154201741 cites W2029085000 @default.
• W3154201741 cites W2036160783 @default.
• W3154201741 cites W2042678305 @default.
• W3154201741 cites W2043018886 @default.
• W3154201741 cites W2056323559 @default.
• W3154201741 cites W2056801474 @default.
• W3154201741 cites W2059968215 @default.
• W3154201741 cites W2076763195 @default.
• W3154201741 cites W2088869170 @default.
• W3154201741 cites W2095551478 @default.
• W3154201741 cites W2103946141 @default.
• W3154201741 cites W2132303297 @default.
• W3154201741 cites W2139234952 @default.
• W3154201741 cites W2144732109 @default.
• W3154201741 cites W2330539862 @default.
• W3154201741 cites W2336620627 @default.
• W3154201741 cites W2463741422 @default.
• W3154201741 cites W2499744716 @default.
• W3154201741 cites W2529548011 @default.
• W3154201741 cites W2605582901 @default.
• W3154201741 cites W2609953325 @default.
• W3154201741 cites W2620853110 @default.
• W3154201741 cites W2626943537 @default.
• W3154201741 cites W2730325637 @default.
• W3154201741 cites W2731770913 @default.
• W3154201741 cites W2734240116 @default.
• W3154201741 cites W2760412699 @default.
• W3154201741 cites W2804541679 @default.
• W3154201741 cites W2804721038 @default.
• W3154201741 cites W2846529151 @default.
• W3154201741 cites W2884994758 @default.
• W3154201741 cites W2889849480 @default.
• W3154201741 cites W2915107095 @default.
• W3154201741 cites W2954144121 @default.
• W3154201741 cites W2969180417 @default.
• W3154201741 cites W2982629815 @default.
• W3154201741 cites W767147494 @default.
• W3154201741 doi "https://doi.org/10.3390/ph14040380" @default.
• W3154201741 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8073600" @default.
• W3154201741 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33921725" @default.
• W3154201741 hasPublicationYear "2021" @default.
• W3154201741 type Work @default.
• W3154201741 sameAs 3154201741 @default.
• W3154201741 citedByCount "8" @default.
• W3154201741 countsByYear W31542017412021 @default.
• W3154201741 countsByYear W31542017412022 @default.
• W3154201741 countsByYear W31542017412023 @default.
• W3154201741 crossrefType "journal-article" @default.
• W3154201741 hasAuthorship W3154201741A5027004265 @default.
• W3154201741 hasAuthorship W3154201741A5034387560 @default.
• W3154201741 hasAuthorship W3154201741A5040342258 @default.
• W3154201741 hasAuthorship W3154201741A5066324893 @default.
• W3154201741 hasBestOaLocation W31542017411 @default.
• W3154201741 hasConcept C118552586 @default.
• W3154201741 hasConcept C126322002 @default.
• W3154201741 hasConcept C164027704 @default.
• W3154201741 hasConcept C2776151105 @default.
• W3154201741 hasConcept C2776467144 @default.
• W3154201741 hasConcept C2776914184 @default.
• W3154201741 hasConcept C2777172819 @default.
• W3154201741 hasConcept C2778186239 @default.
• W3154201741 hasConcept C2780545709 @default.
• W3154201741 hasConcept C71924100 @default.
• W3154201741 hasConcept C87753298 @default.
• W3154201741 hasConcept C98274493 @default.
• W3154201741 hasConceptScore W3154201741C118552586 @default.
• W3154201741 hasConceptScore W3154201741C126322002 @default.
• W3154201741 hasConceptScore W3154201741C164027704 @default.
• W3154201741 hasConceptScore W3154201741C2776151105 @default.
• W3154201741 hasConceptScore W3154201741C2776467144 @default.
• W3154201741 hasConceptScore W3154201741C2776914184 @default.
• W3154201741 hasConceptScore W3154201741C2777172819 @default.
• W3154201741 hasConceptScore W3154201741C2778186239 @default.
• W3154201741 hasConceptScore W3154201741C2780545709 @default.
• W3154201741 hasConceptScore W3154201741C71924100 @default.
• W3154201741 hasConceptScore W3154201741C87753298 @default.
• W3154201741 hasConceptScore W3154201741C98274493 @default.
• W3154201741 hasIssue "4" @default.
• W3154201741 hasLocation W31542017411 @default.
• W3154201741 hasLocation W31542017412 @default.
• W3154201741 hasOpenAccess W3154201741 @default.
• W3154201741 hasPrimaryLocation W31542017411 @default.
• W3154201741 hasRelatedWork W2092272732 @default.

• next