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• W3154260167 abstract "To clarify the association between serum vitamin D levels and its receptor polymorphisms with glaucoma risk.A meta-analysis was performed from available studies investigating serum vitamin D levels and vitamin D receptor (VDR) polymorphisms in glaucoma patients and controls.Twelve studies in total, including 130,676 and 476 subjects, were analysed for the association between serum vitamin D levels and VDR polymorphisms with glaucoma, respectively. Collectively, it was found that glaucoma patients have lower levels of vitamin D compared to controls (SMD = −1.16, 95% CI = −1.56– −0.76, P < 0.00001). In parallel, the pooled results showed a significant association between glaucoma and allelic (b vs. B, OR = 1.84, 95% CI = 1.37–2.46, P = 0.00001) and recessive (bb vs. Bb + BB, OR = 3.16, 95% CI = 1.30–7.66, P = 0.001) models of VDR BsmI (rs1544410) polymorphism, but not with VDR TaqI (rs731236) or FokI (rs2228570) polymorphisms.This meta-analysis suggests that patients with glaucoma may have vitamin D deficiency. In addition, the vitamin D signalling cascade may be a contributing factor in developing glaucoma, which is supported by the evidence that b allele carriers of VDR BsmI exhibited an increase in the risk of glaucoma. Thus, dietary supplementation of vitamin D may become an important approach as an additional treatment for glaucoma.Classifier l’association entre les taux sériques de vitamine D et les polymorphismes de ses récepteurs et le risque de developper un glaucome.Une méta-analyse a été réalisée à partir des études disponibles sur les taux sériques de vitamine D et les polymorphismes des récepteurs de la vitamine D (VDR) chez les patients atteints de glaucome et les témoins.Au total, 12 études, incluant 130 676 et 476 sujets, ont été analysées pour l’association entre les niveaux sériques de vitamine D et les polymorphismes VDR avec le glaucome, respectivement. Collectivement, il a été constaté qu’un patient atteint de glaucome avait un niveau de vitamine D inférieur à celui des témoins (SMD = −1.16, IC à 95% = −1.56– −0.76, p < 0.00001). Parallèlement, les résultats regroupés ont montré une association significative entre le glaucome et les modèles alléliques (b vs. B, OR = 1.84, IC à 95% = 1.37–2.46, p = 0.00001) et récessifs (bb vs. Bb + BB, OR = 3.16, IC à 95% = 1.30–7.66, p = 0,001) de polymorphisme VDR BsmI (rs1544410), mais pas aux polymorphismes VDR TaqI (rs731236) et FokI (rs2228570).Cette méta-analyse suggère que les patients atteints de glaucome peuvent présenter une carence en vitamine D. De plus, la cascade de signalisation de la vitamine D peut être un facteur contribuant au développement du glaucome, ce qui est soutenu par le fait que les porteurs d’allèles b de VDR BsmI présentaient une augmentation du risque de glaucome. Ainsi, la supplémentation alimentaire en vitamine D peut devenir une approche importante comme traitement supplémentaire pour le glaucome." @default.
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• W3154260167 date "2021-04-01" @default.
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• W3154260167 title "Optical genome mapping for assessment of genomic aberrations in acute myeloid leukemia: a multicenter evaluation" @default.
• W3154260167 doi "https://doi.org/10.1016/s1096-7192(21)00422-4" @default.
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