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- W3154264991 abstract "Pre-eclampsia (PE) is a devastating systemic disease which results in maternal hypertension with multi-organ failure due to angiogenic imbalance, characterized by lack of circulating pro-angiogenic factors and excess of anti-angiogenic factors. These factors are crucial for understanding the pathophysiology of PE since they serve as a critical link from placental dysfunction to the clinical syndrome of systemic endothelial dysfunction in the disease. Moreover, utilizing these angiogenic/anti-angiogenic biomarkers can be helpful in risk stratifying and the early detection of PE, which allows for timely intervention to improve maternal and neonatal outcomes. In this review, we summarize updated perspectives of the angiogenic imbalance in PE with detailed characterization of key factors involved in the pathogenesis and how the developed biomarkers can be used in clinical settings as diagnostic tools and as possible therapeutic targets of PE." @default.
- W3154264991 created "2021-04-26" @default.
- W3154264991 creator A5019978733 @default.
- W3154264991 creator A5044235194 @default.
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- W3154264991 date "2021-05-01" @default.
- W3154264991 modified "2023-09-23" @default.
- W3154264991 title "Clinical implications of placenta-derived angiogenic/anti-angiogenic biomarkers in pre-eclampsia" @default.
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- W3154264991 doi "https://doi.org/10.2217/bmm-2020-0545" @default.
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