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- W3154348747 abstract "Summary The gene encoding epidermal growth factor receptor (EGFR) is a major driver gene in cancer. Many drugs targeting EGFR-associated molecules have been developed, yet many have failed in clinical trials due to a lack of efficacy and/or unexpected side effects. In this study, I used image-based phenotypic profiling to screen a pharmacologically active compound library with the aim of identifying new druggable targets in the EGFR pathway. As anticipated, the phenotypic screen identified compounds that produce phenotypes resulting from targeting a known specific molecule or pathway. The assay also showed that compounds with diverse known mechanisms of action produced similar, EGFR-related cellular phenotypes. Biochemical assays revealed that those compounds share a previously unappreciated common target/pathway, showing that the image-based assay can identify new target molecules that are independent of the compound’s known target. Further experiments showed that ROCK1 and PSMD2 are novel druggable targets within the EGFR pathway." @default.
- W3154348747 created "2021-04-26" @default.
- W3154348747 creator A5046391729 @default.
- W3154348747 date "2021-04-17" @default.
- W3154348747 modified "2023-09-27" @default.
- W3154348747 title "Image-based phenotypic profiling of a chemogenomic screening library identifies novel druggable targets in the EGFR-pathway" @default.
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- W3154348747 doi "https://doi.org/10.1101/2021.04.16.440090" @default.
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