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- W3154454711 abstract "Cardiovascular disease (CVD) has long been the leading cause of death worldwide, and myocardial infarction (MI) accounts for the greatest proportion of CVD. Recent research has revealed that inflammation plays a major role in the pathogenesis of CVD and other manifestations of atherosclerosis. Overwhelming evidence supports the view that macrophages, as the basic cell component of the innate immune system, play a pivotal role in atherosclerosis initiation and progression. Limited but indispensable resident macrophages have been detected in the healthy heart; however, the number of cardiac macrophages significantly increases during cardiac injury. In the early period of initial cardiac damage (e.g., MI), numerous classically activated macrophages (M1) originating from the bone marrow and spleen are rapidly recruited to damaged sites, where they are responsible for cardiac remodeling. After the inflammatory stage, the macrophages shift toward an alternatively activated phenotype (M2) that promotes cardiac repair. In addition, extensive studies have shown the therapeutic potential of macrophages as targets, especially for emerging nanoparticle-mediated drug delivery systems. In the present review, we focused on the role of macrophages in the development and progression of MI, factors regulating macrophage activation and function, and the therapeutic potential of macrophages in MI." @default.
- W3154454711 created "2021-04-26" @default.
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- W3154454711 date "2021-04-18" @default.
- W3154454711 modified "2023-10-08" @default.
- W3154454711 title "New Insights and Novel Therapeutic Potentials for Macrophages in Myocardial Infarction" @default.
- W3154454711 cites W1518095394 @default.
- W3154454711 cites W1563932064 @default.
- W3154454711 cites W1798026529 @default.
- W3154454711 cites W1923917571 @default.
- W3154454711 cites W1967369695 @default.
- W3154454711 cites W1969038150 @default.
- W3154454711 cites W1973433801 @default.
- W3154454711 cites W1977979649 @default.
- W3154454711 cites W1985502949 @default.
- W3154454711 cites W1985858162 @default.
- W3154454711 cites W1989741387 @default.
- W3154454711 cites W1994451429 @default.
- W3154454711 cites W1998457769 @default.
- W3154454711 cites W2003870922 @default.
- W3154454711 cites W2004945550 @default.
- W3154454711 cites W2005400104 @default.
- W3154454711 cites W2010239439 @default.
- W3154454711 cites W2010484682 @default.
- W3154454711 cites W2010876644 @default.
- W3154454711 cites W2015141049 @default.
- W3154454711 cites W2018128871 @default.
- W3154454711 cites W2019047698 @default.
- W3154454711 cites W2020744745 @default.
- W3154454711 cites W2030148186 @default.
- W3154454711 cites W2030441151 @default.
- W3154454711 cites W2035031252 @default.
- W3154454711 cites W2035904396 @default.
- W3154454711 cites W2036632357 @default.
- W3154454711 cites W2038689279 @default.
- W3154454711 cites W2040176672 @default.
- W3154454711 cites W2041663579 @default.
- W3154454711 cites W2042194454 @default.
- W3154454711 cites W2053463540 @default.
- W3154454711 cites W2054472394 @default.
- W3154454711 cites W2054540776 @default.
- W3154454711 cites W2060167203 @default.
- W3154454711 cites W2061510929 @default.
- W3154454711 cites W2064316640 @default.
- W3154454711 cites W2065210647 @default.
- W3154454711 cites W2074544404 @default.
- W3154454711 cites W2076043169 @default.
- W3154454711 cites W2077783099 @default.
- W3154454711 cites W2080539468 @default.
- W3154454711 cites W2089520473 @default.
- W3154454711 cites W2091637866 @default.
- W3154454711 cites W2092250990 @default.
- W3154454711 cites W2094941678 @default.
- W3154454711 cites W2095525101 @default.
- W3154454711 cites W2095537212 @default.
- W3154454711 cites W2096179876 @default.
- W3154454711 cites W2098108405 @default.
- W3154454711 cites W2098142645 @default.
- W3154454711 cites W2098954540 @default.
- W3154454711 cites W2099039944 @default.
- W3154454711 cites W2100646399 @default.
- W3154454711 cites W2103863906 @default.
- W3154454711 cites W2106557745 @default.
- W3154454711 cites W2107915827 @default.
- W3154454711 cites W2111035891 @default.
- W3154454711 cites W2113934014 @default.
- W3154454711 cites W2115457290 @default.
- W3154454711 cites W2123950519 @default.
- W3154454711 cites W2125843274 @default.
- W3154454711 cites W2126747203 @default.
- W3154454711 cites W2127401341 @default.
- W3154454711 cites W2140380746 @default.
- W3154454711 cites W2142242761 @default.
- W3154454711 cites W2144120552 @default.
- W3154454711 cites W2144327104 @default.
- W3154454711 cites W2146803540 @default.
- W3154454711 cites W2148898943 @default.
- W3154454711 cites W2149161770 @default.
- W3154454711 cites W2152533590 @default.
- W3154454711 cites W2153406260 @default.
- W3154454711 cites W2159560463 @default.
- W3154454711 cites W2163486647 @default.
- W3154454711 cites W2257033524 @default.
- W3154454711 cites W2267503251 @default.
- W3154454711 cites W2324841714 @default.
- W3154454711 cites W2345479752 @default.
- W3154454711 cites W2482213414 @default.
- W3154454711 cites W2532147058 @default.
- W3154454711 cites W2565271826 @default.
- W3154454711 cites W2569777176 @default.