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- W3154455784 endingPage "167002" @default.
- W3154455784 startingPage "167002" @default.
- W3154455784 abstract "Potassium channels play critical roles in many physiological processes, providing a selective permeation route for K+ ions in and out of a cell, by employing a carefully designed selectivity filter, evolutionarily conserved from viruses to mammals. The structure of the selectivity filter was determined at atomic resolution by x-ray crystallography, showing a tight coordination of desolvated K+ ions by the channel. However, the molecular mechanism of K+ ions permeation through potassium channels remains unclear, with structural, functional and computational studies often providing conflicting data and interpretations. In this review, we will present the proposed mechanisms, discuss their origins, and will critically assess them against all available data. General properties shared by all potassium channels are introduced first, followed by the introduction of two main mechanisms of ion permeation: soft and direct knock-on. Then, we will discuss critical computational and experimental studies that shaped the field. We will especially focus on molecular dynamics (MD) simulations, that provided mechanistic and energetic aspects of K+ permeation, but at the same time created long-standing controversies. Further challenges and possible solutions are presented as well." @default.
- W3154455784 created "2021-04-26" @default.
- W3154455784 creator A5002086598 @default.
- W3154455784 creator A5021312696 @default.
- W3154455784 creator A5030524633 @default.
- W3154455784 creator A5044839728 @default.
- W3154455784 date "2021-08-01" @default.
- W3154455784 modified "2023-10-12" @default.
- W3154455784 title "The Persistent Question of Potassium Channel Permeation Mechanisms" @default.
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