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- W315445909 abstract "The c-MYC proto-oncogene encodes a nuclear phosphoprotein with a lengthy history in the genesis of a variety of malignancies (reviewed in Marcu et al. 1992). The definition of normal c-MYC control pathways should reveal initiating events leading to normal and abnormal cellular growth. Numerous positive and negative regulatory elements have been reported for the c-MYC gene which regulate transcription from two initiation sites specified by the P1 and/or P2 promoters (Marcu et al. 1992). MElal, a nuclear factor site at +97 to +118 with respect to P1, has been identified by deletional mutagenesis as being necessary for efficient P2 initiation (Asselin et al. 1989). In addition to a 180 nucleotide (nt) sequence within the gene’s first exon, MElal was also required for transcriptional blockage of P2 initiated transcripts (Miller et al. 1989). Furthermore, attenuation of P1 initiated transcripts was shown to be dependent upon sequences residing between P1 and P2, inclusive of the MElal site (Wright et al. 1991). The 180 nt P2 termination region and the sequences residing between P1 and P2 can functionally substitute for one another as attenuators (Wright et al. 1991) A close comparison of the sequences required for P1 and P2 blockage has revealed a region in the P2 attenuator region homologous to the MElal site. In addition, another ME1a1-like sequence has been reported in the termination region of the human C2 gene (Ashfield et al. 1991). The MEla2 nuclear factor site, residing between +57 to +82 has also been implicated in P2 initiation (Asselin et al. 1989; Moberg et al. 1992).KeywordsMaltose Binding ProteinNegative Regulatory ElementPolyalanine TractCrude Nuclear ExtractMethylation InterferenceThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
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- W315445909 date "1992-01-01" @default.
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- W315445909 title "Cloning and Characterization of DNA Binding Factors Which Bind Sequences Required for Proper c-myc Initiation" @default.
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- W315445909 doi "https://doi.org/10.1007/978-3-642-77633-5_54" @default.
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