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- W3154459714 endingPage "111274" @default.
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- W3154459714 abstract "This study explores the effects of fecal microbiota from children with vitamin A (VA) deficiency on colonic mucosal barrier function.The composition of gut microbes was identified in children with different VA levels, then feces from children with normal VA or VA deficiency was collected separately and transplanted into germ-free (GF) mice, respectively. Three weeks after transplantation, the colon morphology, colonic tight junction proteins, gut microbes, and metabolites were evaluated.In children, Bifidobacterium and Bacteroides were positively correlated with VA levels. Colonization of VA deficiency fecal microbiota markedly impaired colonic development in GF mice, down-regulated colonic tight junction-related proteins occludin and claudin-1, and reduced immunoglobulin A secretion. Furthermore, fecal microbiota transplantation with different VA levels altered composition of gut microbes and bile acid metabolism pathways in GF mice.These data suggest that fecal microbiota from children with VA deficiency attenuates colonic barrier function in GF mice, which may be achieved by changing the bile acid metabolic pathways." @default.
- W3154459714 created "2021-04-26" @default.
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- W3154459714 date "2021-10-01" @default.
- W3154459714 modified "2023-10-06" @default.
- W3154459714 title "Fecal microbiota from children with vitamin A deficiency impair colonic barrier function in germ-free mice: The possible role of alterative bile acid metabolites" @default.
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- W3154459714 doi "https://doi.org/10.1016/j.nut.2021.111274" @default.
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