FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3154493485> ?p ?o ?g. }

• W3154493485 abstract "Neuroinflammation is a major driver of age-related brain degeneration and concomitant functional impairment. In patients with Alzheimer's disease, the most common form of age-related dementia, factors that enhance neuroinflammation may exacerbate disease progression, in part by impairing the glymphatic system responsible for clearance of pathogenic beta-amyloid. Inflammatory bowel diseases (IBDs) induce neuroinflammation and exacerbate cognitive impairment in the elderly. The NACHT-LRR and pyrin (PYD) domain-containing protein 3 (NLRP3) inflammasome has been implicated in neuroinflammation. Therefore, we examined if the NLRP3 inflammasome contributes to glymphatic dysfunction and cognitive impairment in an aging mouse model of IBD.Sixteen-month-old C57BL/6J and NLRP3 knockout (KO) mice received 1% wt/vol dextran sodium sulfate (DSS) in drinking water to model IBD. Colitis induction was confirmed by histopathology. Exploratory behavior was examined in the open field, associative memory by the novel-object recognition and Morris water maze tests, glymphatic clearance by in vivo two-photon imaging, and neuroinflammation by immunofluorescence and western blotting detection of inflammatory markers.Administration of DSS induced colitis, impaired spatial and recognition memory, activated microglia, and increased A1-like astrocyte numbers. In addition, DSS treatment impaired glymphatic clearance, aggravated amyloid plaque accumulation, and induced neuronal loss in the cortex and hippocampus. These neurodegenerative responses were associated with increased NLRP3 inflammasome expression and accumulation of gut-derived T lymphocytes along meningeal lymphatic vessels. Conversely, NLRP3 depletion protected against cognitive dysfunction, neuroinflammation, and neurological damage induced by DSS.Colitis can exacerbate age-related neuropathology, while suppression of NLRP3 inflammasome activity may protect against these deleterious effects of colitis." @default.
• W3154493485 created "2021-04-26" @default.
• W3154493485 creator A5005630480 @default.
• W3154493485 creator A5006945645 @default.
• W3154493485 creator A5014661038 @default.
• W3154493485 creator A5016888447 @default.
• W3154493485 creator A5024176882 @default.
• W3154493485 creator A5031574668 @default.
• W3154493485 creator A5032808401 @default.
• W3154493485 creator A5054420363 @default.
• W3154493485 creator A5079593300 @default.
• W3154493485 date "2021-07-06" @default.
• W3154493485 modified "2023-10-16" @default.
• W3154493485 title "Chronic colitis exacerbates NLRP3-dependent neuroinflammation and cognitive impairment in middle-aged brain" @default.
• W3154493485 cites W1588685142 @default.
• W3154493485 cites W1725757145 @default.
• W3154493485 cites W1969466297 @default.
• W3154493485 cites W1986611577 @default.
• W3154493485 cites W1993976394 @default.
• W3154493485 cites W1994580609 @default.
• W3154493485 cites W1997102994 @default.
• W3154493485 cites W1997923130 @default.
• W3154493485 cites W2025500109 @default.
• W3154493485 cites W2063731747 @default.
• W3154493485 cites W2069895863 @default.
• W3154493485 cites W2094785614 @default.
• W3154493485 cites W2096410114 @default.
• W3154493485 cites W2100314515 @default.
• W3154493485 cites W2118804183 @default.
• W3154493485 cites W2130947702 @default.
• W3154493485 cites W2155704304 @default.
• W3154493485 cites W2156744949 @default.
• W3154493485 cites W2165279131 @default.
• W3154493485 cites W2167183660 @default.
• W3154493485 cites W2203834014 @default.
• W3154493485 cites W2261157573 @default.
• W3154493485 cites W2301880294 @default.
• W3154493485 cites W2326974508 @default.
• W3154493485 cites W2332044667 @default.
• W3154493485 cites W2354779203 @default.
• W3154493485 cites W2460079419 @default.
• W3154493485 cites W2531211739 @default.
• W3154493485 cites W2572710398 @default.
• W3154493485 cites W2592980662 @default.
• W3154493485 cites W2593036876 @default.
• W3154493485 cites W2614586381 @default.
• W3154493485 cites W2770964951 @default.
• W3154493485 cites W2789700981 @default.
• W3154493485 cites W2789949980 @default.
• W3154493485 cites W2790139801 @default.
• W3154493485 cites W2803118356 @default.
• W3154493485 cites W2803229974 @default.
• W3154493485 cites W2811371297 @default.
• W3154493485 cites W2883628966 @default.
• W3154493485 cites W2892318814 @default.
• W3154493485 cites W2895939677 @default.
• W3154493485 cites W2898255378 @default.
• W3154493485 cites W2901075243 @default.
• W3154493485 cites W2904489586 @default.
• W3154493485 cites W2911518744 @default.
• W3154493485 cites W2945327298 @default.
• W3154493485 cites W2949125436 @default.
• W3154493485 cites W2950595223 @default.
• W3154493485 cites W2964087368 @default.
• W3154493485 cites W2969822493 @default.
• W3154493485 cites W2981755996 @default.
• W3154493485 cites W3001780488 @default.
• W3154493485 cites W3023837377 @default.
• W3154493485 cites W3030165573 @default.
• W3154493485 cites W3044413849 @default.
• W3154493485 doi "https://doi.org/10.1186/s12974-021-02199-8" @default.
• W3154493485 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8262017" @default.
• W3154493485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34229722" @default.
• W3154493485 hasPublicationYear "2021" @default.
• W3154493485 type Work @default.
• W3154493485 sameAs 3154493485 @default.
• W3154493485 citedByCount "40" @default.
• W3154493485 countsByYear W31544934852022 @default.
• W3154493485 countsByYear W31544934852023 @default.
• W3154493485 crossrefType "journal-article" @default.
• W3154493485 hasAuthorship W3154493485A5005630480 @default.
• W3154493485 hasAuthorship W3154493485A5006945645 @default.
• W3154493485 hasAuthorship W3154493485A5014661038 @default.
• W3154493485 hasAuthorship W3154493485A5016888447 @default.
• W3154493485 hasAuthorship W3154493485A5024176882 @default.
• W3154493485 hasAuthorship W3154493485A5031574668 @default.
• W3154493485 hasAuthorship W3154493485A5032808401 @default.
• W3154493485 hasAuthorship W3154493485A5054420363 @default.
• W3154493485 hasAuthorship W3154493485A5079593300 @default.
• W3154493485 hasBestOaLocation W31544934851 @default.
• W3154493485 hasConcept C126322002 @default.
• W3154493485 hasConcept C142724271 @default.
• W3154493485 hasConcept C15744967 @default.
• W3154493485 hasConcept C169760540 @default.
• W3154493485 hasConcept C203014093 @default.
• W3154493485 hasConcept C2776914184 @default.
• W3154493485 hasConcept C2777209026 @default.
• W3154493485 hasConcept C2779830541 @default.
• W3154493485 hasConcept C2781161787 @default.
• W3154493485 hasConcept C44752575 @default.

• next