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- W3154498625 endingPage "100693" @default.
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- W3154498625 abstract "To indicate the EIIA protein of cellobiose-specific phosphotransferase transport system in affecting the characterization and virulence of Streptococcus agalactiae. A △cel-EIIA mutant was constructed from the wild-type S. agalactiae THN0901 strain by homologous recombination. In the present study, the cellobiose metabolism and biofilm formation of the △cel-EIIA mutant was significantly decreased, relative to that of the wild-type S. agalactiae THN0901. The proliferation capacity in vitro and the invasion and colonization ability in vivo of the △cel-EIIA mutant was also significantly lower than that of S. agalactiae THN0901. Furthermore, in tilapia infection model, the lethal dose 50 % the △cel-EIIA mutant was significantly higher than that of the wild strain. Taken together, the cel-EIIA gene plays a positive role in S. agalactiae cellobiose metabolism, biofilm formation and colonization of tilapia. The results of this study provide the basic data for the cellobiose metabolism and virulence mechanism in S. agalactiae of tilapia in the future." @default.
- W3154498625 created "2021-04-26" @default.
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- W3154498625 date "2021-07-01" @default.
- W3154498625 modified "2023-09-26" @default.
- W3154498625 title "Characterization and virulence of Streptococcus agalactiae deficient in EIIA of the cellobiose-specific phosphotransferase system" @default.
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- W3154498625 doi "https://doi.org/10.1016/j.aqrep.2021.100693" @default.
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