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- W3154546564 abstract "Abstract Adolescents with migraine have different functional connectivity of the amygdala compared to individuals without migraine. Considering that sleep is often disturbed in those adolescents with migrane, this study examined if measures of subjective and objective (actigraphic) sleep difficulties mediate alterations in amygdalar connectivity in adolescents with migraine compared to healthy adolescents. Twenty adolescents with migraine and 20 healthy controls completed surveys about their headaches and overall sleep quality, sleep hygiene and perceived sleep difficulties, wore a wrist-worn actigraphy, and underwent an MRI scan. Adolescents with migraine differed from healthy controls only in perceived sleep difficulties related to sleep initiation and maintenance ( p <0.01) and had greater functional connectivity between the amygdala and the posterior cingulate cortex, precuneus, dorsolateral prefrontal, sensorimotor, and the occipital cortexes. While the mediation model showed group differences in subjective and actigraphic sleep difficulties, these did not mediate the differences in amygdalar connectivity found between the groups. Adolescents with migraine have greater connectivity between the amygdala and areas involved in sensory, affective, and cognitive aspects of pain. These alterations may not be due to higher levels of sleep difficulties in adolescents with migraine, suggesting that both amygdala and sleep alterations may play an independent role in migraine pathophysiology Perspective This article evaluates the role plays by sleep on neural alterations in adolescents with migraine. It indicates that neural alterations due to migraine are not related to alterations in subjective and actigraphic sleep difficulties. This advances the understanding of the mechanisms underlying pediatric migraine and can potentially advance migraine management." @default.
- W3154546564 created "2021-04-26" @default.
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- W3154546564 date "2021-04-13" @default.
- W3154546564 modified "2023-09-24" @default.
- W3154546564 title "New Insight into the Neural Mechanisms of Migraine in Adolescents: Relationships with Sleep" @default.
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- W3154546564 doi "https://doi.org/10.1101/2021.04.09.21255214" @default.
- W3154546564 hasPublicationYear "2021" @default.