FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3154566752> ?p ?o ?g. }

• W3154566752 abstract "Abstract The Drosophila anterior-posterior (AP) axis is specified at mid-oogenesis when Par-1 kinase is recruited to the posterior cortex of the oocyte, where it polarises the microtubule cytoskeleton to define where the axis determinants, bicoid and oskar mRNAs localise. This polarity is established in response to an unknown signal from the follicle cells, but how this occurs is unclear. Here we show that the myosin chaperone, Unc-45 and Non-Muscle Myosin II (MyoII) are required in the germ line upstream of Par-1 in polarity establishment. Furthermore, the Myosin regulatory Light Chain (MRLC) is di-phosphorylated at the oocyte posterior in response to the follicle cell signal, inducing longer pulses of myosin contractility at the posterior and increased cortical tension. Over-expression of MRLC-T21A that cannot be di-phosphorylated or acute treatment with the Myosin light chain kinase inhibitor ML-7 abolish Par-1 localisation, indicating that posterior of MRLC di-phosphorylation is essential for polarity. Thus, asymmetric myosin activation polarizes the anterior-posterior axis by recruiting and maintaining Par-1 at the posterior cortex. This raises an intriguing parallel with AP axis formation in C. elegans where MyoII is also required to establish polarity, but functions to localize the anterior PAR proteins rather than PAR-1." @default.
• W3154566752 created "2021-04-26" @default.
• W3154566752 creator A5026006748 @default.
• W3154566752 creator A5027640574 @default.
• W3154566752 creator A5061822047 @default.
• W3154566752 date "2021-04-21" @default.
• W3154566752 modified "2023-09-23" @default.
• W3154566752 title "TheDrosophilaanterior-posterior axis is polarized by asymmetric myosin activation" @default.
• W3154566752 cites W1018855955 @default.
• W3154566752 cites W1546918094 @default.
• W3154566752 cites W1555563809 @default.
• W3154566752 cites W1566790599 @default.
• W3154566752 cites W1961449438 @default.
• W3154566752 cites W1965769301 @default.
• W3154566752 cites W1971913477 @default.
• W3154566752 cites W1972076214 @default.
• W3154566752 cites W1974781802 @default.
• W3154566752 cites W1976226144 @default.
• W3154566752 cites W1980793772 @default.
• W3154566752 cites W1984414342 @default.
• W3154566752 cites W1987817703 @default.
• W3154566752 cites W1988367343 @default.
• W3154566752 cites W1992327628 @default.
• W3154566752 cites W1995757732 @default.
• W3154566752 cites W2003460583 @default.
• W3154566752 cites W2009301533 @default.
• W3154566752 cites W2015407080 @default.
• W3154566752 cites W2015852214 @default.
• W3154566752 cites W2028638994 @default.
• W3154566752 cites W2030029307 @default.
• W3154566752 cites W2030274279 @default.
• W3154566752 cites W2035657497 @default.
• W3154566752 cites W2040125277 @default.
• W3154566752 cites W2048781606 @default.
• W3154566752 cites W2049718632 @default.
• W3154566752 cites W2052190647 @default.
• W3154566752 cites W2054314420 @default.
• W3154566752 cites W2057989418 @default.
• W3154566752 cites W2060686949 @default.
• W3154566752 cites W2061212583 @default.
• W3154566752 cites W2063197874 @default.
• W3154566752 cites W2068920904 @default.
• W3154566752 cites W2081580757 @default.
• W3154566752 cites W2092245168 @default.
• W3154566752 cites W2100270425 @default.
• W3154566752 cites W2104950425 @default.
• W3154566752 cites W2107662757 @default.
• W3154566752 cites W2110858653 @default.
• W3154566752 cites W2114056852 @default.
• W3154566752 cites W2123008200 @default.
• W3154566752 cites W2129274773 @default.
• W3154566752 cites W2135482336 @default.
• W3154566752 cites W2162049443 @default.
• W3154566752 cites W2166254523 @default.
• W3154566752 cites W2185119839 @default.
• W3154566752 cites W2464788944 @default.
• W3154566752 cites W2470019017 @default.
• W3154566752 cites W2563591290 @default.
• W3154566752 cites W2623385074 @default.
• W3154566752 cites W269334237 @default.
• W3154566752 cites W2742344312 @default.
• W3154566752 cites W2747562273 @default.
• W3154566752 cites W2762248661 @default.
• W3154566752 cites W2766997643 @default.
• W3154566752 cites W2898751564 @default.
• W3154566752 cites W2908806522 @default.
• W3154566752 cites W2921524095 @default.
• W3154566752 cites W2922121615 @default.
• W3154566752 cites W2980969119 @default.
• W3154566752 cites W3006603801 @default.
• W3154566752 cites W4242882744 @default.
• W3154566752 doi "https://doi.org/10.1101/2021.04.21.440791" @default.
• W3154566752 hasPublicationYear "2021" @default.
• W3154566752 type Work @default.
• W3154566752 sameAs 3154566752 @default.
• W3154566752 citedByCount "1" @default.
• W3154566752 countsByYear W31545667522023 @default.
• W3154566752 crossrefType "posted-content" @default.
• W3154566752 hasAuthorship W3154566752A5026006748 @default.
• W3154566752 hasAuthorship W3154566752A5027640574 @default.
• W3154566752 hasAuthorship W3154566752A5061822047 @default.
• W3154566752 hasBestOaLocation W31545667521 @default.
• W3154566752 hasConcept C11960822 @default.
• W3154566752 hasConcept C1491633281 @default.
• W3154566752 hasConcept C196843134 @default.
• W3154566752 hasConcept C2776690073 @default.
• W3154566752 hasConcept C2777361361 @default.
• W3154566752 hasConcept C55493867 @default.
• W3154566752 hasConcept C6997183 @default.
• W3154566752 hasConcept C8035138 @default.
• W3154566752 hasConcept C86803240 @default.
• W3154566752 hasConcept C95444343 @default.
• W3154566752 hasConceptScore W3154566752C11960822 @default.
• W3154566752 hasConceptScore W3154566752C1491633281 @default.
• W3154566752 hasConceptScore W3154566752C196843134 @default.
• W3154566752 hasConceptScore W3154566752C2776690073 @default.
• W3154566752 hasConceptScore W3154566752C2777361361 @default.
• W3154566752 hasConceptScore W3154566752C55493867 @default.
• W3154566752 hasConceptScore W3154566752C6997183 @default.
• W3154566752 hasConceptScore W3154566752C8035138 @default.

• next