Matches in SemOpenAlex for { <https://semopenalex.org/work/W3154642099> ?p ?o ?g. }
- W3154642099 abstract "Abstract Naturally abundant quinones are important molecules, which play essential roles in various biological processes due to their reduction potential. In contrast to their universality, the investigation of reactions between quinones and proteins remains sparse. Herein, we report the development of a convenient strategy to protein modification via a biomimetic quinone-mediated oxidation at the N -terminus. By exploiting unique reactivity of an ortho- quinone reagent, the α-amine of protein N -terminus is oxidized to generate aldo or keto handle for orthogonal conjugation. The applications have been demonstrated using a range of proteins, including myoglobin, ubiquitin and small ubiquitin-related modifier 2 (SUMO2). The effect of this method is further highlighted via the preparation of a series of 17 macrophage inflammatory protein 1β (MIP-1β) analogs, followed by preliminary anti-HIV activity and cell viability assays, respectively. This method offers an efficient and complementary approach to existing strategies for N -terminal modification of proteins." @default.
- W3154642099 created "2021-04-26" @default.
- W3154642099 creator A5009277330 @default.
- W3154642099 creator A5009768750 @default.
- W3154642099 creator A5009795051 @default.
- W3154642099 creator A5013736647 @default.
- W3154642099 creator A5031390739 @default.
- W3154642099 creator A5040814799 @default.
- W3154642099 creator A5046173291 @default.
- W3154642099 creator A5076498328 @default.
- W3154642099 creator A5091070290 @default.
- W3154642099 date "2021-04-15" @default.
- W3154642099 modified "2023-10-14" @default.
- W3154642099 title "Modification of N-terminal α-amine of proteins via biomimetic ortho-quinone-mediated oxidation" @default.
- W3154642099 cites W109583564 @default.
- W3154642099 cites W1506412310 @default.
- W3154642099 cites W1968944419 @default.
- W3154642099 cites W1974414796 @default.
- W3154642099 cites W1980196568 @default.
- W3154642099 cites W1984811742 @default.
- W3154642099 cites W1989914749 @default.
- W3154642099 cites W1997579149 @default.
- W3154642099 cites W2006824068 @default.
- W3154642099 cites W2017598323 @default.
- W3154642099 cites W2023141752 @default.
- W3154642099 cites W2025470424 @default.
- W3154642099 cites W2026764033 @default.
- W3154642099 cites W2029661897 @default.
- W3154642099 cites W2029932803 @default.
- W3154642099 cites W2031142152 @default.
- W3154642099 cites W2036757553 @default.
- W3154642099 cites W2037460653 @default.
- W3154642099 cites W2039871617 @default.
- W3154642099 cites W2043820375 @default.
- W3154642099 cites W2057650441 @default.
- W3154642099 cites W2060746246 @default.
- W3154642099 cites W2062205832 @default.
- W3154642099 cites W2067964854 @default.
- W3154642099 cites W2080915808 @default.
- W3154642099 cites W2094620274 @default.
- W3154642099 cites W2107773522 @default.
- W3154642099 cites W2109648693 @default.
- W3154642099 cites W2116582201 @default.
- W3154642099 cites W2125789393 @default.
- W3154642099 cites W2130892977 @default.
- W3154642099 cites W2171303848 @default.
- W3154642099 cites W2313926965 @default.
- W3154642099 cites W2320249261 @default.
- W3154642099 cites W2320276891 @default.
- W3154642099 cites W2323898578 @default.
- W3154642099 cites W2331302493 @default.
- W3154642099 cites W2333026048 @default.
- W3154642099 cites W2334196837 @default.
- W3154642099 cites W2509279282 @default.
- W3154642099 cites W2513641908 @default.
- W3154642099 cites W2523580724 @default.
- W3154642099 cites W2568910234 @default.
- W3154642099 cites W2594396234 @default.
- W3154642099 cites W2670390373 @default.
- W3154642099 cites W2735736903 @default.
- W3154642099 cites W2753987807 @default.
- W3154642099 cites W2754072457 @default.
- W3154642099 cites W2790053493 @default.
- W3154642099 cites W2810164223 @default.
- W3154642099 cites W2892279005 @default.
- W3154642099 cites W2901331699 @default.
- W3154642099 cites W2911305013 @default.
- W3154642099 cites W2951747643 @default.
- W3154642099 cites W2960787887 @default.
- W3154642099 cites W2965522644 @default.
- W3154642099 cites W2970885146 @default.
- W3154642099 cites W2973675131 @default.
- W3154642099 cites W3016603210 @default.
- W3154642099 cites W3028245233 @default.
- W3154642099 cites W3044492184 @default.
- W3154642099 cites W3080473439 @default.
- W3154642099 cites W390491255 @default.
- W3154642099 cites W4211074777 @default.
- W3154642099 cites W4213262935 @default.
- W3154642099 cites W4231385139 @default.
- W3154642099 cites W4252073564 @default.
- W3154642099 doi "https://doi.org/10.1038/s41467-021-22654-7" @default.
- W3154642099 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8050078" @default.
- W3154642099 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33859198" @default.
- W3154642099 hasPublicationYear "2021" @default.
- W3154642099 type Work @default.
- W3154642099 sameAs 3154642099 @default.
- W3154642099 citedByCount "21" @default.
- W3154642099 countsByYear W31546420992021 @default.
- W3154642099 countsByYear W31546420992022 @default.
- W3154642099 countsByYear W31546420992023 @default.
- W3154642099 crossrefType "journal-article" @default.
- W3154642099 hasAuthorship W3154642099A5009277330 @default.
- W3154642099 hasAuthorship W3154642099A5009768750 @default.
- W3154642099 hasAuthorship W3154642099A5009795051 @default.
- W3154642099 hasAuthorship W3154642099A5013736647 @default.
- W3154642099 hasAuthorship W3154642099A5031390739 @default.
- W3154642099 hasAuthorship W3154642099A5040814799 @default.
- W3154642099 hasAuthorship W3154642099A5046173291 @default.
- W3154642099 hasAuthorship W3154642099A5076498328 @default.