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• W3154654321 endingPage "2100090" @default.
• W3154654321 startingPage "2100090" @default.
• W3154654321 abstract "Currently, radiotherapy (RT) is the main method for cancer treatment. However, the hypoxic environment of solid tumors is likely to cause resistance or failure of RT. Moreover, high-dose radiation may cause side effects to surrounding normal tissues. In this study, a new type of nanozyme is developed by doping Mn (II) ions into Ag2Se quantum dots (QDs) emitting in the second near-infrared window (NIR-II, 1000–1700 nm). Through the catalysis of Mn (II) ions, the nanozymes can trigger the rapid decomposition of H2O2 and produce O2. Conjugated with tumor-targeting arginine-glycine-aspartate (RGD) tripeptides and polyethylene glycol (PEG) molecules, the nanozymes are then constructed into in vivo nanoprobes for NIR-II imaging-guided RT of tumors. Owing to the radiosensitive activity of the element Ag, the nanoprobes can promote radiation energy deposition. The specific tumor-targeting and NIR-II emitting abilities of the nanoprobes facilitate the precise tumor localization, which enables precise RT with low side effects. Moreover, their ultra-stability in the living body ensures that the nanoprobes continuously produce oxygen and relieve the hypoxia of tumors to enhance RT efficacy. Guided by real-time and high-clarity imaging, the nanoprobe-mediated RT promotes anti-tumor immunity, which significantly inhibits the growth of tumors or even cures them completely." @default.
• W3154654321 created "2021-04-26" @default.
• W3154654321 creator A5003578005 @default.
• W3154654321 creator A5006266198 @default.
• W3154654321 creator A5019560977 @default.
• W3154654321 creator A5036522093 @default.
• W3154654321 creator A5036726873 @default.
• W3154654321 creator A5049918341 @default.
• W3154654321 creator A5065761001 @default.
• W3154654321 creator A5082534213 @default.
• W3154654321 date "2021-04-22" @default.
• W3154654321 modified "2023-10-15" @default.
• W3154654321 title "An Ultra‐Stable, Oxygen‐Supply Nanoprobe Emitting in Near‐Infrared‐II Window to Guide and Enhance Radiotherapy by Promoting Anti‐Tumor Immunity" @default.
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