Matches in SemOpenAlex for { <https://semopenalex.org/work/W3154671194> ?p ?o ?g. }
- W3154671194 abstract "Although major advances in genomics have initiated an exciting new era of research, a lack of information regarding cis-regulatory elements has limited the genetic improvement or manipulation of pigs as a meat source and biomedical model. Here, we systematically characterize cis-regulatory elements and their functions in 12 diverse tissues from four pig breeds by adopting similar strategies as the ENCODE and Roadmap Epigenomics projects, which include RNA-seq, ATAC-seq, and ChIP-seq. In total, we generate 199 datasets and identify more than 220,000 cis-regulatory elements in the pig genome. Surprisingly, we find higher conservation of cis-regulatory elements between human and pig genomes than those between human and mouse genomes. Furthermore, the differences of topologically associating domains between the pig and human genomes are associated with morphological evolution of the head and face. Beyond generating a major new benchmark resource for pig epigenetics, our study provides basic comparative epigenetic data relevant to using pigs as models in human biomedical research." @default.
- W3154671194 created "2021-04-26" @default.
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- W3154671194 date "2021-04-13" @default.
- W3154671194 modified "2023-10-10" @default.
- W3154671194 title "A compendium and comparative epigenomics analysis of cis-regulatory elements in the pig genome" @default.
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