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- W3154674003 abstract "In the direct competition for metabolic resources between cancer cells and tumor-infiltrating CD8+ T cells, the latter are bound to lose out. These effector lymphocytes are therefore rendered exhausted or dysfunctional. Emerging insights into the mechanisms of T cell unresponsiveness in the tumor microenvironment (TME) point towards epigenetic mechanisms as crucial regulatory factors. In this review, we discuss the effects of characteristic components of the TME, i.e. glucose/amino acid dearth with elevated levels of reactive oxygen species (ROS), on DNA methylation and histone modifications in CD8+ T cells. We then take a closer look at the translational potential of epigenetic interventions that aim to improve current immunotherapeutic strategies, including the adoptive transfer of T cell receptor (TCR) or chimeric antigen receptor (CAR) engineered T cells." @default.
- W3154674003 created "2021-04-26" @default.
- W3154674003 creator A5023652242 @default.
- W3154674003 creator A5027179416 @default.
- W3154674003 creator A5054930067 @default.
- W3154674003 creator A5065036894 @default.
- W3154674003 creator A5081131425 @default.
- W3154674003 date "2021-05-01" @default.
- W3154674003 modified "2023-10-18" @default.
- W3154674003 title "How metabolism bridles cytotoxic CD8+ T cells through epigenetic modifications" @default.
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