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- W3154675071 abstract "It is well established fact that peptides from various foods offer human health benefits displaying diverse functionalities. Millets considered as super foods is a major alternative in recent days for traditional diet being rich in proteins and fibre along with trace minerals and vitamins. In this connection, proteins from Buckwheat and Quinoa were digested by in vitro simulation digestion for the generation of peptides, analyzed by nLC-MS/MS and the functional annotations of the identified proteins/peptides were carried out. The study led to the identification of 34 small peptides and their parent proteins clustered into 4 gene functional groups and their localization prediction indicated their involvement in energy metabolism, transport and storage. Interestingly, the identified peptides maximally displayed DPP-IV and ACE inhibitions. The present study was extended to unravel ACE-2 inhibition targeting COVID-19 by selecting ACE-2-Spike binding domain for molecular docking studies. The NWRTVKYG interacted with the ACE-2-Spike interface displaying the feasible binding energy (- 213.63) and docking score (- 12.43) and the MD simulation revealed the ability of the peptide in stabilizing the protein-peptide composite. The present investigation thus establishes newer vista for food derived peptides having ACE-2 inhibitory potential as tentative strategy for SARS-CoV-2 therapeutics." @default.
- W3154675071 created "2021-04-26" @default.
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- W3154675071 date "2021-04-08" @default.
- W3154675071 modified "2023-10-18" @default.
- W3154675071 title "Identification of Potential Peptide Inhibitors of ACE-2 Target of SARS-CoV-2 from Buckwheat & Quinoa" @default.
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- W3154675071 cites W1966238900 @default.
- W3154675071 cites W1972181794 @default.
- W3154675071 cites W1975630793 @default.
- W3154675071 cites W2005813245 @default.
- W3154675071 cites W2006211612 @default.
- W3154675071 cites W2012991711 @default.
- W3154675071 cites W2023500726 @default.
- W3154675071 cites W2028067373 @default.
- W3154675071 cites W2030096525 @default.
- W3154675071 cites W2035266068 @default.
- W3154675071 cites W2038300255 @default.
- W3154675071 cites W2039663472 @default.
- W3154675071 cites W2041376597 @default.
- W3154675071 cites W2042770759 @default.
- W3154675071 cites W2057477511 @default.
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- W3154675071 cites W2134318288 @default.
- W3154675071 cites W2145604940 @default.
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- W3154675071 cites W2171038067 @default.
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- W3154675071 cites W2237253233 @default.
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- W3154675071 cites W2314647217 @default.
- W3154675071 cites W2345479383 @default.
- W3154675071 cites W2420659973 @default.
- W3154675071 cites W2538852319 @default.
- W3154675071 cites W2541896623 @default.
- W3154675071 cites W2586414653 @default.
- W3154675071 cites W2593843857 @default.
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- W3154675071 cites W2646353165 @default.
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- W3154675071 cites W2801407028 @default.
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- W3154675071 cites W2909749057 @default.
- W3154675071 cites W2921484024 @default.
- W3154675071 cites W2928152462 @default.
- W3154675071 cites W2941184643 @default.
- W3154675071 cites W2941618195 @default.
- W3154675071 cites W2943029408 @default.
- W3154675071 cites W2954126005 @default.
- W3154675071 cites W2990504906 @default.
- W3154675071 cites W2999364275 @default.
- W3154675071 cites W3004348779 @default.
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- W3154675071 cites W3007397583 @default.
- W3154675071 cites W3008142620 @default.
- W3154675071 cites W3008295344 @default.
- W3154675071 cites W3009939474 @default.
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- W3154675071 cites W3020695284 @default.
- W3154675071 cites W3025152376 @default.
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- W3154675071 cites W4211087249 @default.
- W3154675071 cites W845847446 @default.
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- W3154675071 doi "https://doi.org/10.1007/s10989-021-10211-1" @default.
- W3154675071 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8030649" @default.
- W3154675071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33850482" @default.
- W3154675071 hasPublicationYear "2021" @default.
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