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• W3154689689 abstract "Alveolar type 2 (AT2) cells are heterogeneous cells, with specialised AT2 subpopulations within this lineage exhibiting stem cell properties. However, the existence of quiescent, immature cells within the AT2 lineage that are activated during lung regeneration is unknown. Sftpc CreERT2/+ ;tdTomato flox/flox mice were used for the labelling of AT2 cells and labelled subpopulations were analysed by flow cytometry, quantitative PCR, assay for transposase-accessible chromatin using sequencing (ATAC-seq), gene arrays, pneumonectomy and culture of precision-cut lung slices. Single-cell RNA-sequencing (scRNA-seq) data from human lungs were analysed. In mice, we detected two distinct AT2 subpopulations, with low tdTomato level (Tom Low ) and high tdTomato level (Tom High ). Tom Low cells express lower levels of the AT2 differentiation markers Fgfr2b and Etv5 , while Tom High , as bona fide mature AT2 cells, show higher levels of Sftpc , Sftpb , Sftpa1 , Fgfr2b and Etv5 expression. ATAC-seq analysis indicates that Tom Low and Tom High cells constitute two distinct cell populations, with specific silencing of Sftpc , Rosa26 and cell cycle gene loci in the Tom Low population. Upon pneumonectomy, the number of Tom Low but not Tom High cells increases and Tom Low cells show upregulated expression of Fgfr2b , Etv5 , Sftpc , Ccnd1 and Ccnd2 compared to Sham. Tom Low cells overexpress programmed cell death 1 ligand 1 (PD-L1), an immune inhibitory membrane receptor ligand, which is used by flow cytometry to differentially isolate these two subpopulations. In the human lung, data mining of a recent scRNA-seq AT2 data set demonstrates the existence of a PD-L1 Pos population. Therefore, we have identified a novel population of AT2 quiescent, immature progenitor cells in mouse that expand upon pneumonectomy and we have provided evidence for the existence of such cells in human." @default.
• W3154689689 created "2021-04-26" @default.
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• W3154689689 date "2021-04-16" @default.
• W3154689689 modified "2023-10-17" @default.
• W3154689689 title "Identification of a novel subset of alveolar type 2 cells enriched in PD-L1 and expanded following pneumonectomy" @default.
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• W3154689689 doi "https://doi.org/10.1183/13993003.04168-2020" @default.
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