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• W3154753912 abstract "IgE is an antibody produced by the immune system in response to helminth and parasites, and it has previously been found to be involved in eczema, ichthyosis, and lupus, among other skin disorders (Bayry, 2016; Johansson et al., 2017; Kiritsi et al., 2015). According to twin and family studies, genetic factors affect total IgE levels, and their heritability was estimated as 36‒78% (Jacobsen et al., 2001; Meyers et al., 1987). GWASs of total IgE levels in European populations (two studies in 14,628 and 11,299 German individuals and one study in 8,539 Latino individuals) identified SNPs near FCER1A, IL13, signal transducer and activator of transcription gene (i.e., STAT6), and ZNF365 (Granada et al., 2012; Moffatt et al., 2010; Pino-Yanes et al., 2015; Weidinger et al., 2008), whereas GWASs of total IgE levels in Asian populations (three studies in 3,654 Japanese individuals, 877 Korean individuals, and 3,495 Chinese individuals, respectively) identified no significant loci other than the major histocompatibility complex region (Kim et al., 2013; Liao et al., 2013; Yatagai et al., 2013) (summarized in Supplementary Table S1)." @default.
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• W3154753912 date "2021-11-01" @default.
• W3154753912 modified "2023-10-14" @default.
• W3154753912 title "GWAS Identified IL4R and the Major Histocompatibility Complex Region as the Associated Loci of Total Serum IgE Levels in 9,260 Japanese Individuals" @default.
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• W3154753912 doi "https://doi.org/10.1016/j.jid.2021.02.762" @default.
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