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- W3154755512 endingPage "4138" @default.
- W3154755512 startingPage "4138" @default.
- W3154755512 abstract "Natural products are widely used as source for drugs development. An interesting example is represented by natural drugs developed against human topoisomerase IB, a ubiquitous enzyme involved in many cellular processes where several topological problems occur due the formation of supercoiled DNA. Human topoisomerase IB, involved in the solution of such problems relaxing the DNA cleaving and religating a single DNA strand, represents an important target in anticancer therapy. Several natural compounds inhibiting or poisoning this enzyme are under investigation as possible new drugs. This review summarizes the natural products that target human topoisomerase IB that may be used as the lead compounds to develop new anticancer drugs. Moreover, the natural compounds and their derivatives that are in clinical trial are also commented on." @default.
- W3154755512 created "2021-04-26" @default.
- W3154755512 creator A5019534523 @default.
- W3154755512 creator A5025388120 @default.
- W3154755512 creator A5053084129 @default.
- W3154755512 creator A5073611920 @default.
- W3154755512 date "2021-04-16" @default.
- W3154755512 modified "2023-09-26" @default.
- W3154755512 title "Natural Compounds as Therapeutic Agents: The Case of Human Topoisomerase IB" @default.
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