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- W3154756898 abstract "This thesis outlines the preparation of polymeric micelles between boronic acid-functionalized PEG-dendritic block copolymers and diol-containing drugs, as a promising strategy in drug delivery. Taking advantage of terminal azide groups for functionalization, PEG-GATG dendritic block copolymers with peripheral boronic acids were obtained via reductive amination with 2-formylphenylboronic. The ability of the resulting boronic acid-functionalized copolymers (PEG-[G3]-BO2H2) to encapsulate drugs incorporating 1,2- and 1,3-diols into micelles, via selective boronic ester formation, was assessed in aqueous media at pH 7.4. Gemcitabine, an anticancer drug was selected for a deeper study. After incorporation into micelles in the presence of catechol, the encapsulation efficiency and stability of the micelles were determined, and their toxicity profile studied." @default.
- W3154756898 created "2021-04-26" @default.
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- W3154756898 date "2020-01-01" @default.
- W3154756898 modified "2023-09-26" @default.
- W3154756898 title "Dendritic Boronic Acids for the Delivery of Diol-containing Drugs" @default.
- W3154756898 hasPublicationYear "2020" @default.
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