FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3154760929> ?p ?o ?g. }

• W3154760929 endingPage "3023" @default.
• W3154760929 startingPage "3011" @default.
• W3154760929 abstract "Background: Cancer-associated fibroblasts (CAFs) are principal constituents of the tumor microenvironment (TME) and play a critical role in tumor progression. The CXCL12/CXCR4 axis regulates multiple facets of the TME. The aim of this study was to determine the relationship between CXCL12 expression in CAFs and the malignant progression of gastric cancer (GC). Methods: In the GEO (Gene Expression Omnibus) database, we performed transcriptome analysis on paired gastric cancer RNA sequencing samples, and scRNA analysis was performed on advanced malignant GC samples from the scRNA sequencing data set. Fibroblast cells were co-cultured with GC cells, and invasion, migration, epithelial-mesenchymal transformation (EMT) were determined. After blocking the expression of fibroblast CXCL12, cells were co-cultured with a GC cell line. Detection of GC cell line invasion, migration, EMT and CXCR4, Wnt5a and β-Catenin expression levels was performed. Primary CAFs and gastric normal fibroblasts were isolated and CXCL12 mRNA and protein expression were determined. In addition, a cohort of 285 GC cases was established, protein expression was evaluated immunohistochemically, and prognostic results were analyzed. Results: GC transcriptome analysis suggested that cytokine-cytokine receptor interaction and the Wnt signaling pathway in GC tissues were significantly up-regulated. scRNA analysis of advanced malignant GC samples showed that severe intestinal metaplasia (SIM) in GC specimens of different malignant grades had obvious fibroblast clusters compared to non-atrophic gastritis (NAG) and early gastric cancer (EGC). In the SIM group, fibroblast cluster, CXCL12, CXCR4, and Wnt5a were overexpressed. Co-culturing with fibroblast cells significantly increased the invasion, migration, and EMT of GC cells, and blocking CXCL12 in CAFs disturbed the expression of Wnt5a and β-catenin. In our cohort of GC patients, high CXCL12 expression in CAFs significantly correlated with histological grade (P = 0.012) and TNM stage (P = 0.014), as well as with poor overall survival (p = 0.0107). Conclusion: High expression of CXCL12 in CAFs in a GC microenvironment can affect the migration, invasion, and EMT of GC cells. Furthermore, it can cause poor prognosis in patients with GC." @default.
• W3154760929 created "2021-04-26" @default.
• W3154760929 creator A5002661071 @default.
• W3154760929 creator A5002768111 @default.
• W3154760929 creator A5019493045 @default.
• W3154760929 creator A5023282229 @default.
• W3154760929 creator A5027605982 @default.
• W3154760929 creator A5040384421 @default.
• W3154760929 creator A5043070856 @default.
• W3154760929 creator A5053780153 @default.
• W3154760929 creator A5059430503 @default.
• W3154760929 creator A5075394139 @default.
• W3154760929 date "2021-01-01" @default.
• W3154760929 modified "2023-10-16" @default.
• W3154760929 title "Cancer-associated fibroblasts in gastric cancer affect malignant progression via the CXCL12-CXCR4 axis" @default.
• W3154760929 cites W1971070564 @default.
• W3154760929 cites W1972287875 @default.
• W3154760929 cites W2000378305 @default.
• W3154760929 cites W2037834427 @default.
• W3154760929 cites W2063870592 @default.
• W3154760929 cites W2077781719 @default.
• W3154760929 cites W2113472355 @default.
• W3154760929 cites W2123782854 @default.
• W3154760929 cites W2136546686 @default.
• W3154760929 cites W2213893071 @default.
• W3154760929 cites W2217482725 @default.
• W3154760929 cites W2559009215 @default.
• W3154760929 cites W2604329262 @default.
• W3154760929 cites W2746455523 @default.
• W3154760929 cites W2756072256 @default.
• W3154760929 cites W2759988730 @default.
• W3154760929 cites W2765224588 @default.
• W3154760929 cites W2766595152 @default.
• W3154760929 cites W2767820894 @default.
• W3154760929 cites W2772199817 @default.
• W3154760929 cites W2783562764 @default.
• W3154760929 cites W2786302594 @default.
• W3154760929 cites W2804132492 @default.
• W3154760929 cites W2847139828 @default.
• W3154760929 cites W2884255528 @default.
• W3154760929 cites W2904766033 @default.
• W3154760929 cites W2944311410 @default.
• W3154760929 cites W2967207814 @default.
• W3154760929 cites W2980456345 @default.
• W3154760929 cites W3013675309 @default.
• W3154760929 doi "https://doi.org/10.7150/jca.49707" @default.
• W3154760929 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8040897" @default.
• W3154760929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33854601" @default.
• W3154760929 hasPublicationYear "2021" @default.
• W3154760929 type Work @default.
• W3154760929 sameAs 3154760929 @default.
• W3154760929 citedByCount "20" @default.
• W3154760929 countsByYear W31547609292021 @default.
• W3154760929 countsByYear W31547609292022 @default.
• W3154760929 countsByYear W31547609292023 @default.
• W3154760929 crossrefType "journal-article" @default.
• W3154760929 hasAuthorship W3154760929A5002661071 @default.
• W3154760929 hasAuthorship W3154760929A5002768111 @default.
• W3154760929 hasAuthorship W3154760929A5019493045 @default.
• W3154760929 hasAuthorship W3154760929A5023282229 @default.
• W3154760929 hasAuthorship W3154760929A5027605982 @default.
• W3154760929 hasAuthorship W3154760929A5040384421 @default.
• W3154760929 hasAuthorship W3154760929A5043070856 @default.
• W3154760929 hasAuthorship W3154760929A5053780153 @default.
• W3154760929 hasAuthorship W3154760929A5059430503 @default.
• W3154760929 hasAuthorship W3154760929A5075394139 @default.
• W3154760929 hasBestOaLocation W31547609291 @default.
• W3154760929 hasConcept C121608353 @default.
• W3154760929 hasConcept C126322002 @default.
• W3154760929 hasConcept C129470790 @default.
• W3154760929 hasConcept C13373296 @default.
• W3154760929 hasConcept C143998085 @default.
• W3154760929 hasConcept C15744967 @default.
• W3154760929 hasConcept C2776035688 @default.
• W3154760929 hasConcept C2776914184 @default.
• W3154760929 hasConcept C46312422 @default.
• W3154760929 hasConcept C502942594 @default.
• W3154760929 hasConcept C71924100 @default.
• W3154760929 hasConceptScore W3154760929C121608353 @default.
• W3154760929 hasConceptScore W3154760929C126322002 @default.
• W3154760929 hasConceptScore W3154760929C129470790 @default.
• W3154760929 hasConceptScore W3154760929C13373296 @default.
• W3154760929 hasConceptScore W3154760929C143998085 @default.
• W3154760929 hasConceptScore W3154760929C15744967 @default.
• W3154760929 hasConceptScore W3154760929C2776035688 @default.
• W3154760929 hasConceptScore W3154760929C2776914184 @default.
• W3154760929 hasConceptScore W3154760929C46312422 @default.
• W3154760929 hasConceptScore W3154760929C502942594 @default.
• W3154760929 hasConceptScore W3154760929C71924100 @default.
• W3154760929 hasIssue "10" @default.
• W3154760929 hasLocation W31547609291 @default.
• W3154760929 hasLocation W31547609292 @default.
• W3154760929 hasOpenAccess W3154760929 @default.
• W3154760929 hasPrimaryLocation W31547609291 @default.
• W3154760929 hasRelatedWork W2042520059 @default.
• W3154760929 hasRelatedWork W2109763600 @default.
• W3154760929 hasRelatedWork W2392089463 @default.
• W3154760929 hasRelatedWork W2771066073 @default.

• next