FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3154862483> ?p ?o ?g. }

• W3154862483 endingPage "1347" @default.
• W3154862483 startingPage "1331" @default.
• W3154862483 abstract "Both glucose tolerance and adaptive immune function exhibit significant age-related alterations. The influence of the immune system on obesity-associated glucose intolerance is well characterized; however, whether the immune system contributes to age-related glucose intolerance is not as well understood. Here, we report that advancing age results in an increase in T cell infiltration in the epididymal white adipose tissue (eWAT), liver, and skeletal muscle. Subtype analyses show that both CD4+, CD8+ T cells are greater with advancing age in each of these tissues and that aging results in a blunted CD4 to CD8 ratio. Anti-CD3 F(ab’)2 fragments depleted CD4+ and CD8+ cells in eWAT, CD4+ cells only in the liver, and did not deplete quadriceps T cells. In old mice, T cells producing both interferon-γ and tumor necrosis factor-α are accumulated in the eWAT and liver, and a greater proportion of skeletal muscle T cells produced interferon-γ. Aging resulted in increased proportion and numbers of T regulatory cells in eWAT, but not in the liver or muscle. Aging also resulted in greater numbers of eWAT and quadriceps CD206- macrophages and eWAT, liver and quadriceps B cells; neither cell type was altered by anti-CD3 treatment. Anti-CD3 treatment improved glucose tolerance in old mice and was accompanied by improved signaling related to liver and skeletal muscle insulin utilization and decreased gluconeogenesis-related gene expression in the liver. Our findings indicate a critical role of the adaptive immune system in the age-related metabolic dysfunction." @default.
• W3154862483 created "2021-04-26" @default.
• W3154862483 creator A5003953922 @default.
• W3154862483 creator A5016143340 @default.
• W3154862483 creator A5020399339 @default.
• W3154862483 creator A5021880961 @default.
• W3154862483 creator A5027126385 @default.
• W3154862483 creator A5037456121 @default.
• W3154862483 creator A5057585798 @default.
• W3154862483 creator A5075109445 @default.
• W3154862483 creator A5083118197 @default.
• W3154862483 creator A5087946903 @default.
• W3154862483 date "2021-04-24" @default.
• W3154862483 modified "2023-10-14" @default.
• W3154862483 title "T lymphocyte depletion ameliorates age-related metabolic impairments in mice" @default.
• W3154862483 cites W1966336914 @default.
• W3154862483 cites W1969457517 @default.
• W3154862483 cites W1979158927 @default.
• W3154862483 cites W2004469794 @default.
• W3154862483 cites W2008869160 @default.
• W3154862483 cites W2078407186 @default.
• W3154862483 cites W2082622955 @default.
• W3154862483 cites W2086581449 @default.
• W3154862483 cites W2090822920 @default.
• W3154862483 cites W2094296565 @default.
• W3154862483 cites W2110630581 @default.
• W3154862483 cites W2112516812 @default.
• W3154862483 cites W2112992750 @default.
• W3154862483 cites W2113511371 @default.
• W3154862483 cites W2150702412 @default.
• W3154862483 cites W2153512876 @default.
• W3154862483 cites W2158365429 @default.
• W3154862483 cites W2158370855 @default.
• W3154862483 cites W2165202791 @default.
• W3154862483 cites W2165334726 @default.
• W3154862483 cites W2165678812 @default.
• W3154862483 cites W2176575827 @default.
• W3154862483 cites W2269067703 @default.
• W3154862483 cites W2276466435 @default.
• W3154862483 cites W2509220708 @default.
• W3154862483 cites W2516581072 @default.
• W3154862483 cites W2521232955 @default.
• W3154862483 cites W2551984653 @default.
• W3154862483 cites W2560805164 @default.
• W3154862483 cites W2563328378 @default.
• W3154862483 cites W2606788958 @default.
• W3154862483 cites W2736294384 @default.
• W3154862483 cites W2775167938 @default.
• W3154862483 cites W2806587405 @default.
• W3154862483 cites W2809854831 @default.
• W3154862483 cites W2886808233 @default.
• W3154862483 cites W2888191704 @default.
• W3154862483 cites W2891409258 @default.
• W3154862483 cites W2984169107 @default.
• W3154862483 cites W3031560054 @default.
• W3154862483 doi "https://doi.org/10.1007/s11357-021-00368-4" @default.
• W3154862483 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8190228" @default.
• W3154862483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33893902" @default.
• W3154862483 hasPublicationYear "2021" @default.
• W3154862483 type Work @default.
• W3154862483 sameAs 3154862483 @default.
• W3154862483 citedByCount "12" @default.
• W3154862483 countsByYear W31548624832021 @default.
• W3154862483 countsByYear W31548624832022 @default.
• W3154862483 countsByYear W31548624832023 @default.
• W3154862483 crossrefType "journal-article" @default.
• W3154862483 hasAuthorship W3154862483A5003953922 @default.
• W3154862483 hasAuthorship W3154862483A5016143340 @default.
• W3154862483 hasAuthorship W3154862483A5020399339 @default.
• W3154862483 hasAuthorship W3154862483A5021880961 @default.
• W3154862483 hasAuthorship W3154862483A5027126385 @default.
• W3154862483 hasAuthorship W3154862483A5037456121 @default.
• W3154862483 hasAuthorship W3154862483A5057585798 @default.
• W3154862483 hasAuthorship W3154862483A5075109445 @default.
• W3154862483 hasAuthorship W3154862483A5083118197 @default.
• W3154862483 hasAuthorship W3154862483A5087946903 @default.
• W3154862483 hasBestOaLocation W31548624832 @default.
• W3154862483 hasConcept C126322002 @default.
• W3154862483 hasConcept C134018914 @default.
• W3154862483 hasConcept C151955695 @default.
• W3154862483 hasConcept C167672396 @default.
• W3154862483 hasConcept C171089720 @default.
• W3154862483 hasConcept C203014093 @default.
• W3154862483 hasConcept C2776090121 @default.
• W3154862483 hasConcept C2777761686 @default.
• W3154862483 hasConcept C2779959927 @default.
• W3154862483 hasConcept C71924100 @default.
• W3154862483 hasConcept C86803240 @default.
• W3154862483 hasConcept C8891405 @default.
• W3154862483 hasConceptScore W3154862483C126322002 @default.
• W3154862483 hasConceptScore W3154862483C134018914 @default.
• W3154862483 hasConceptScore W3154862483C151955695 @default.
• W3154862483 hasConceptScore W3154862483C167672396 @default.
• W3154862483 hasConceptScore W3154862483C171089720 @default.
• W3154862483 hasConceptScore W3154862483C203014093 @default.
• W3154862483 hasConceptScore W3154862483C2776090121 @default.
• W3154862483 hasConceptScore W3154862483C2777761686 @default.
• W3154862483 hasConceptScore W3154862483C2779959927 @default.

• next