FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3154888085> ?p ?o ?g. }

• W3154888085 endingPage "1185" @default.
• W3154888085 startingPage "1179" @default.
• W3154888085 abstract "Aims In RCT of adults with decompensated cirrhosis, GCSF mobilizes hematopoietic stem cells HSC and improves short-term outcome. An FDA-IND for sequential Kasai-GCSF treatment in biliary atresia BA was approved. This phase 1 study examines GCSF safety in Kasai subjects. Preliminary short-term outcome was evaluated. Methods GCSF (Neupogen) at 5 or 10 μg/kg (n = 3/group) was given in 3 daily doses starting on day 3 of Kasai surgery (NCT03395028). Serum CD34+ HSC cell counts, and 1-month of GCSF-related adverse events were monitored. The 6-months Phase 1 clinical outcome was compared against 10 subsequent post Phase 1 Kasai patients who did not receive GCSF. Results With GCSF, WBC and platelet count transiently increased, LFT and serum creatinine remained stable. Reversible splenic enlargement (by 8.5–20%) occurred in 5/6 subjects. HSC count increased 12-fold and 17.5-fold for the 5 μg/kg and10 ug/kg dose respectively; with respective median total bilirubin levels for GCSF vs no-GCSF groups of 55 vs 91 μM at 1 month, p = 0.05; 15 vs 37 μM at 3 months, p = 0.24); and the 6-months cholangitis frequency of 40% vs 90%, p = 0.077. Conclusions GCSF safely mobilizes HSC in Kasai infants and may improve short-term biliary drainage and cholangitis. Phase 2 efficacy outcome of GCSF adjunct therapy for sequential Kasai and GCSF is pending." @default.
• W3154888085 created "2021-04-26" @default.
• W3154888085 creator A5015900335 @default.
• W3154888085 creator A5017466832 @default.
• W3154888085 creator A5021072590 @default.
• W3154888085 creator A5028311021 @default.
• W3154888085 creator A5033465652 @default.
• W3154888085 creator A5034913821 @default.
• W3154888085 creator A5037850363 @default.
• W3154888085 creator A5045060358 @default.
• W3154888085 creator A5072654059 @default.
• W3154888085 creator A5073338061 @default.
• W3154888085 creator A5083504650 @default.
• W3154888085 date "2021-07-01" @default.
• W3154888085 modified "2023-10-07" @default.
• W3154888085 title "Granulocyte-colony stimulating factor GCSF mobilizes hematopoietic stem cells in Kasai patients with biliary atresia in a phase 1 study and improves short term outcome" @default.
• W3154888085 cites W1548457745 @default.
• W3154888085 cites W1869128236 @default.
• W3154888085 cites W1988057223 @default.
• W3154888085 cites W2002391829 @default.
• W3154888085 cites W2003492168 @default.
• W3154888085 cites W2005250390 @default.
• W3154888085 cites W2026013903 @default.
• W3154888085 cites W2030748531 @default.
• W3154888085 cites W2031537391 @default.
• W3154888085 cites W2061730726 @default.
• W3154888085 cites W2063309707 @default.
• W3154888085 cites W2063368082 @default.
• W3154888085 cites W2076231600 @default.
• W3154888085 cites W2087217939 @default.
• W3154888085 cites W2090372962 @default.
• W3154888085 cites W2104554139 @default.
• W3154888085 cites W2113899987 @default.
• W3154888085 cites W2159114947 @default.
• W3154888085 cites W2162984856 @default.
• W3154888085 cites W2172254233 @default.
• W3154888085 cites W2221530085 @default.
• W3154888085 cites W2332279058 @default.
• W3154888085 cites W2522923623 @default.
• W3154888085 cites W2560816498 @default.
• W3154888085 cites W2580494720 @default.
• W3154888085 cites W2724547610 @default.
• W3154888085 cites W2767699210 @default.
• W3154888085 cites W2780700845 @default.
• W3154888085 cites W2794632001 @default.
• W3154888085 cites W2904246627 @default.
• W3154888085 cites W2912552888 @default.
• W3154888085 cites W2947987925 @default.
• W3154888085 cites W4211091180 @default.
• W3154888085 doi "https://doi.org/10.1016/j.jpedsurg.2021.03.038" @default.
• W3154888085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33965236" @default.
• W3154888085 hasPublicationYear "2021" @default.
• W3154888085 type Work @default.
• W3154888085 sameAs 3154888085 @default.
• W3154888085 citedByCount "9" @default.
• W3154888085 countsByYear W31548880852022 @default.
• W3154888085 countsByYear W31548880852023 @default.
• W3154888085 crossrefType "journal-article" @default.
• W3154888085 hasAuthorship W3154888085A5015900335 @default.
• W3154888085 hasAuthorship W3154888085A5017466832 @default.
• W3154888085 hasAuthorship W3154888085A5021072590 @default.
• W3154888085 hasAuthorship W3154888085A5028311021 @default.
• W3154888085 hasAuthorship W3154888085A5033465652 @default.
• W3154888085 hasAuthorship W3154888085A5034913821 @default.
• W3154888085 hasAuthorship W3154888085A5037850363 @default.
• W3154888085 hasAuthorship W3154888085A5045060358 @default.
• W3154888085 hasAuthorship W3154888085A5072654059 @default.
• W3154888085 hasAuthorship W3154888085A5073338061 @default.
• W3154888085 hasAuthorship W3154888085A5083504650 @default.
• W3154888085 hasConcept C126322002 @default.
• W3154888085 hasConcept C141071460 @default.
• W3154888085 hasConcept C2776694085 @default.
• W3154888085 hasConcept C2777214474 @default.
• W3154888085 hasConcept C2777767877 @default.
• W3154888085 hasConcept C2779243279 @default.
• W3154888085 hasConcept C2779609443 @default.
• W3154888085 hasConcept C2911091166 @default.
• W3154888085 hasConcept C71924100 @default.
• W3154888085 hasConcept C90924648 @default.
• W3154888085 hasConceptScore W3154888085C126322002 @default.
• W3154888085 hasConceptScore W3154888085C141071460 @default.
• W3154888085 hasConceptScore W3154888085C2776694085 @default.
• W3154888085 hasConceptScore W3154888085C2777214474 @default.
• W3154888085 hasConceptScore W3154888085C2777767877 @default.
• W3154888085 hasConceptScore W3154888085C2779243279 @default.
• W3154888085 hasConceptScore W3154888085C2779609443 @default.
• W3154888085 hasConceptScore W3154888085C2911091166 @default.
• W3154888085 hasConceptScore W3154888085C71924100 @default.
• W3154888085 hasConceptScore W3154888085C90924648 @default.
• W3154888085 hasFunder F4320316563 @default.
• W3154888085 hasIssue "7" @default.
• W3154888085 hasLocation W31548880851 @default.
• W3154888085 hasOpenAccess W3154888085 @default.
• W3154888085 hasPrimaryLocation W31548880851 @default.
• W3154888085 hasRelatedWork W2026487299 @default.
• W3154888085 hasRelatedWork W2076378012 @default.
• W3154888085 hasRelatedWork W2086163106 @default.
• W3154888085 hasRelatedWork W2094148832 @default.

• next