Matches in SemOpenAlex for { <https://semopenalex.org/work/W3154903409> ?p ?o ?g. }
- W3154903409 endingPage "4082" @default.
- W3154903409 startingPage "4082" @default.
- W3154903409 abstract "The sigma-1 receptor (S1R) is a 223 amino acid-long transmembrane endoplasmic reticulum (ER) protein. The S1R modulates the activity of multiple effector proteins, but its signaling functions are poorly understood. S1R is associated with cholesterol, and in our recent studies we demonstrated that S1R association with cholesterol induces the formation of S1R clusters. We propose that these S1R-cholesterol interactions enable the formation of cholesterol-enriched microdomains in the ER membrane. We hypothesize that a number of secreted and signaling proteins are recruited and retained in these microdomains. This hypothesis is consistent with the results of an unbiased screen for S1R-interacting partners, which we performed using the engineered ascorbate peroxidase 2 (APEX2) technology. We further propose that S1R agonists enable the disassembly of these cholesterol-enriched microdomains and the release of accumulated proteins such as ion channels, signaling receptors, and trophic factors from the ER. This hypothesis may explain the pleotropic signaling functions of the S1R, consistent with previously observed effects of S1R agonists in various experimental systems." @default.
- W3154903409 created "2021-04-26" @default.
- W3154903409 creator A5047722409 @default.
- W3154903409 creator A5051218483 @default.
- W3154903409 creator A5074668880 @default.
- W3154903409 creator A5074925454 @default.
- W3154903409 date "2021-04-15" @default.
- W3154903409 modified "2023-10-14" @default.
- W3154903409 title "Sigma-1 Receptor (S1R) Interaction with Cholesterol: Mechanisms of S1R Activation and Its Role in Neurodegenerative Diseases" @default.
- W3154903409 cites W1040373759 @default.
- W3154903409 cites W1561309798 @default.
- W3154903409 cites W1591398790 @default.
- W3154903409 cites W1622252351 @default.
- W3154903409 cites W1966591733 @default.
- W3154903409 cites W1967171196 @default.
- W3154903409 cites W1967709737 @default.
- W3154903409 cites W1977919486 @default.
- W3154903409 cites W1978909649 @default.
- W3154903409 cites W1979328277 @default.
- W3154903409 cites W1980496079 @default.
- W3154903409 cites W1984662248 @default.
- W3154903409 cites W1987210736 @default.
- W3154903409 cites W1987443998 @default.
- W3154903409 cites W1988491331 @default.
- W3154903409 cites W1991419440 @default.
- W3154903409 cites W1994224293 @default.
- W3154903409 cites W1994289493 @default.
- W3154903409 cites W1995552213 @default.
- W3154903409 cites W2000621526 @default.
- W3154903409 cites W2002332690 @default.
- W3154903409 cites W2002642171 @default.
- W3154903409 cites W2003888864 @default.
- W3154903409 cites W2009803380 @default.
- W3154903409 cites W2010963787 @default.
- W3154903409 cites W2014503023 @default.
- W3154903409 cites W2016855638 @default.
- W3154903409 cites W2019079031 @default.
- W3154903409 cites W2021305292 @default.
- W3154903409 cites W2021399955 @default.
- W3154903409 cites W2023217871 @default.
- W3154903409 cites W2026692772 @default.
- W3154903409 cites W2027564664 @default.
- W3154903409 cites W2031211058 @default.
- W3154903409 cites W2034221484 @default.
- W3154903409 cites W2037506486 @default.
- W3154903409 cites W2040326898 @default.
- W3154903409 cites W2046475919 @default.
- W3154903409 cites W2047453275 @default.
- W3154903409 cites W2047790393 @default.
- W3154903409 cites W2055005801 @default.
- W3154903409 cites W2059115784 @default.
- W3154903409 cites W2060650451 @default.
- W3154903409 cites W2067388722 @default.
- W3154903409 cites W2074000839 @default.
- W3154903409 cites W2076386951 @default.
- W3154903409 cites W2082790399 @default.
- W3154903409 cites W2083105433 @default.
- W3154903409 cites W2087609871 @default.
- W3154903409 cites W2089659493 @default.
- W3154903409 cites W2092902839 @default.
- W3154903409 cites W2096296988 @default.
- W3154903409 cites W2113751655 @default.
- W3154903409 cites W2113937251 @default.
- W3154903409 cites W2114403556 @default.
- W3154903409 cites W2118897192 @default.
- W3154903409 cites W2125368083 @default.
- W3154903409 cites W2130410032 @default.
- W3154903409 cites W2130518310 @default.
- W3154903409 cites W2130750499 @default.
- W3154903409 cites W2131087015 @default.
- W3154903409 cites W2132840236 @default.
- W3154903409 cites W2135855797 @default.
- W3154903409 cites W2137454401 @default.
- W3154903409 cites W2150782426 @default.
- W3154903409 cites W2154267426 @default.
- W3154903409 cites W2155611657 @default.
- W3154903409 cites W2156257893 @default.
- W3154903409 cites W2156975935 @default.
- W3154903409 cites W2158565324 @default.
- W3154903409 cites W2158988264 @default.
- W3154903409 cites W2166131107 @default.
- W3154903409 cites W2167069175 @default.
- W3154903409 cites W2168358500 @default.
- W3154903409 cites W2169525045 @default.
- W3154903409 cites W2189803963 @default.
- W3154903409 cites W2271406622 @default.
- W3154903409 cites W2295351013 @default.
- W3154903409 cites W2313042457 @default.
- W3154903409 cites W2314811232 @default.
- W3154903409 cites W2344348455 @default.
- W3154903409 cites W2469536647 @default.
- W3154903409 cites W2493372949 @default.
- W3154903409 cites W2519867542 @default.
- W3154903409 cites W2547401413 @default.
- W3154903409 cites W2552888741 @default.
- W3154903409 cites W2593415702 @default.
- W3154903409 cites W2594117084 @default.
- W3154903409 cites W2595836464 @default.