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- W3155012268 abstract "Application of advanced imaging methods to OA clinical research has led to a rapid increase in disease understanding and large longitudinal observational studies have added to our understanding of the natural course of osteoarthritis. This presentation will focus on advanced imaging techniques and their application in a clinical, research and clinical trial context. In the last 10 years, joint imaging, particularly MRI, has evolved rapidly. The many developments in MRI techniques capable of assessing cartilage morphology and the methods for evaluating its biochemical composition will be discussed. The use of high spatial resolution techniques to assess articular morphology combined with available compositional techniques will improve the sensitivity of MRI in the detection of early joint degeneration and should strengthen the future role of imaging also in the clinical context. This will be of particular importance once structure- or disease-modifying drugs become available, which will require monitoring the treatment response in large sets of patients with OA. With the availability of such disease-modifying interventions, imaging will likely play an important role in clinical decision-making and practice. Advances in MRI quantitative morphologic cartilage assessment and semi-quantitative whole-organ assessment as well as bone shape quantification will be reviewed, as will other modalities such as ultrasound, computed tomography (CT) including CT arthrography, cone beam and weight bearing CT. Nuclear medicine techniques including hybrid imaging such as PET-MRI play a complementary but increasingly important role that will briefly be presented. The role of advanced imaging in clinical DMOAD trials and NGF inhibitor development will conclude the presentation." @default.
- W3155012268 created "2021-04-26" @default.
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- W3155012268 date "2021-04-01" @default.
- W3155012268 modified "2023-09-28" @default.
- W3155012268 title "New insights in OA through advanced imaging techniques - what do we know and where may we go?" @default.
- W3155012268 doi "https://doi.org/10.1016/j.joca.2021.02.023" @default.
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