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- W3155101165 endingPage "369" @default.
- W3155101165 startingPage "369" @default.
- W3155101165 abstract "To date, natural products are widely used as pharmaceutical agents for many human diseases and cancers. One of the most popular natural products that have been studied for anticancer properties is thymoquinone (TQ). As a bioactive compound of Nigella sativa, TQ has shown anticancer activities through the inhibition of cell proliferation, migration, and invasion. The anticancer efficacy of TQ is being investigated in several human cancers such as pancreatic cancer, breast cancer, colon cancer, hepatic cancer, cervical cancer, and leukemia. Even though TQ induces apoptosis by regulating the expression of pro- apoptotic and anti-apoptotic genes in many cancers, the TQ effect mechanism on such cancers is not yet fully understood. Therefore, the present review has highlighted the TQ effect mechanisms on several signaling pathways and expression of tumor suppressor genes (TSG). Data from relevant published experimental articles on TQ from 2015 to June 2020 were selected by using Google Scholar and PubMed search engines. The present study investigated the effectiveness of TQ alone or in combination with other anticancer therapeutic agents, such as tyrosine kinase inhibitors on cancers, as a future anticancer therapy nominee by using nanotechnology." @default.
- W3155101165 created "2021-04-26" @default.
- W3155101165 creator A5003100188 @default.
- W3155101165 creator A5016027282 @default.
- W3155101165 creator A5050871114 @default.
- W3155101165 creator A5051458952 @default.
- W3155101165 creator A5063746643 @default.
- W3155101165 creator A5064396637 @default.
- W3155101165 creator A5085266571 @default.
- W3155101165 date "2021-04-16" @default.
- W3155101165 modified "2023-10-16" @default.
- W3155101165 title "Thymoquinone, as a Novel Therapeutic Candidate of Cancers" @default.
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