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- W3155111720 abstract "In light of the continued threat of antimicrobial-resistant bacteria, new strategies to expand the repertoire of antimicrobial compounds are necessary. Prodrugs are an underexploited strategy in this effort. Here, we report on the enhanced antimicrobial activity of a prodrug toward bacteria having an enzyme capable of its activation. A screen led us to the sulfurol ester of the antibiotic trans-3-(4-chlorobenzoyl)acrylic acid. An endogenous esterase makes Mycolycibacterium smegmatis sensitive to this prodrug. Candidate esterases were identified, and their heterologous production made Escherichia coli sensitive to the ester prodrug. Taken together, these data suggest a new approach to the development of antimicrobial compounds that takes advantage of endogenous enzymatic activities to target specific bacteria." @default.
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- W3155111720 date "2021-04-20" @default.
- W3155111720 modified "2023-09-27" @default.
- W3155111720 title "Endogenous Enzymes Enable Antimicrobial Activity" @default.
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- W3155111720 doi "https://doi.org/10.1021/acschembio.0c00894" @default.
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