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• W3155123043 abstract "Since little is known about the epidemiology of glomerulopathies (GP) in Romania and there are evidence on the changing prevalence of GP over the years worldwide, the current study aimed to assess the trends in the frequency of biopsy-proven GP in adults admitted to a tertiary, university-affiliated center of Nephrology that provides specialized care to the southeastern region of Romania, over a period of ten years. A retrospective, cross-sectional study was conducted. From the hospital’s kidney biopsy (KB) database subjects with a histological diagnosis of GP between 01.01.2008-31.12.2017 were selected. Exclusion criteria were: age <18 years, biopsy on kidney graft, any repeated biopsy in any patient, and insufficient tissue sample. All selected biopsies were analyzed by light microscopy, immunofluorescence, and electron microscopy. Clinical and laboratory data were extracted from the electronic medical records for all the selected subjects. Demographic, clinical, laboratory, and histological data were compared between subjects who underwent KB in the first and last five years (2008-2012 vs. 2013-2017) of the studied period. A total of 1254 subjects were enrolled, 355 from the first period and 899 from the second. In the last five years subjects were older, with lower eGFR and proteinuria. In both intervals, the main reason for KB was nephrotic syndrome, but its frequence decreased after 2013 (36.7% vs. 53.8%, p<0.001). In addition, chronic renal failure and acute nephritic syndrome were more commonly seen between 2013-2017 (16.1% vs. 5.9%, p<0.001 and 11.5% vs. 6.2%, p=0.005, respectively). The two most frequent biopsy-proven GP (IgA nephropathy followed by membranous nephropathy) had similar proportions in both studied periods. Conversely, diabetic nephropathy and crescentic glomerulonephritis showed increased frequences over time (12.3% vs. 4.8%, p<0.001 and 6.6% vs. 3.1%, p=0.02, respectively), while minimal change disease was more rarely diagnosed (8.8% vs. 14.4%, p<0.001). These findings suggest rather a change in the medical practice concerning native kidney biopsy, than a true change in the prevalence of biopsy-proven GP in adults from the southeastern region of Romania. It seems that over time the indications for performing kidney biopsy have been extended to older patients, with diabetes mellitus, with more severe kidney function decline, and less proteinuria." @default.
• W3155123043 created "2021-04-26" @default.
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• W3155123043 date "2021-04-01" @default.
• W3155123043 modified "2023-10-18" @default.
• W3155123043 title "POS-478 TRENDS IN THE SPECTRUM OF BIOPSY-PROVEN GLOMERULOPATHIES IN ADULTS FROM SOUTH-EASTERN ROMANIA OVER A TEN YEARS PERIOD" @default.
• W3155123043 doi "https://doi.org/10.1016/j.ekir.2021.03.505" @default.
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