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- W3155172404 abstract "Objective To investigate the insulin resistance of normal pregnant women in oral glucose tolerance test (OGTT) and to explore the relationship between insulin resistance and adverse pregnancy outcomes.Methods Totally 457 normal pregnant women who had prenatal examination and delivered in Shanghai Sixth People's Hospital during June 2015 to June 2016 were selected.The biochemical indexes,delivery outcomes and neonatal information of the pregnant women during the delivery period were followed up.According to the homeostasis model assessment-insulin resistance index (HOMA-IR),the cases were divided into two groups,normal group (HOMA-IR ＜ 2.8,n =399) and insulin resistance group (HOMA-IR ≥2.8,n =58).The biochemical indexes and pregnancy outcomes between two groups were analyzed.Results Among 457 normal pregnant women,12.69％ presented insulin resistance.There were significant differences in BMI and systolic blood pressure between insulin resistance group and normal group (t value was-8.740 and-2.438,respectively,both P ＜ 0.05).In biochemical indexes,there were significant differences in high density lipoprotein,uric acid,fasting insulin,1h insulin,2h insulin,fasting blood glucose,2h blood glucose,basal insulin secretion index,mixed insulin sensitivity index (t value was 3.004,-5.998,-22.533,-7.568,-8.744,-6.416,-2.411,-7.316 and 16.692,respectively,all P＜0.05).The neonatal weight in insulin resistance group was slightly higher than that in normal group,and the difference was statistically significant (t =-2.742,P ＜ 0.05).Correlation analysis showed that insulin resistance was positively correlated with the occurrence of macrosomia and hypertensive disorder complicating pregnancy (r value was 0.106 and 0.125,respectively,both P ＜ 0.05).The results of regression analysis showed that insulin resistance was one of the risk factors of macrosomia and hypertensive disorder complicating pregnancy (OR =2.601,95％ CI ranged 1.048 to 6.455;OR =9.092,95％ CI ranged 2.680 to 30.845).There were significant differences between two groups in the incidence of maerosomia and pregnancy induced hypertension (x2 value was 4.526 and 16.516,respectively,both P ＜ 0.05).Conclusion Some of pregnant women with normal blood glucose suffer from insulin resistance.Insulin resistance is one of the risk factors of fetal macrosomia and hypertensive disorders complicating pregnancy,which suggests that relieving insulin resistance can improve maternal and neonatal outcomes." @default.
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- W3155172404 date "2017-01-01" @default.
- W3155172404 modified "2023-09-23" @default.
- W3155172404 title "Influence of insulin resistance on pregnancy outcomes of pregnant women with normal glucose" @default.
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