Matches in SemOpenAlex for { <https://semopenalex.org/work/W3155199462> ?p ?o ?g. }
- W3155199462 endingPage "2014" @default.
- W3155199462 startingPage "2001" @default.
- W3155199462 abstract "Abstract IgZ or its equivalent IgT is a newly discovered teleost specific Ig class that is highly specialized in mucosal immunity. However, whether this IgZ/IgT class participates in other biological processes remains unclear. In this study, we unexpectedly discovered that IgZ is highly expressed in zebrafish ovary, accumulates in unfertilized eggs, and is transmitted to offspring from eggs to zygotes. Maternally transferred IgZ in zygotes is found at the outer and inner layers of chorion, perivitelline space, periphery of embryo body, and yolk, providing different lines of defense against pathogen infection. A considerable number of IgZ+ B cells are found in ovarian connective tissues distributed between eggs. Moreover, pIgR, the transporter of IgZ, is also expressed in the ovary and colocalizes with IgZ in the zona radiata of eggs. Thus, IgZ is possibly secreted by ovarian IgZ+ B cells and transported to eggs through association with pIgR in a paracrine manner. Maternal IgZ in zygotes showed a broad bacteriostatic activity to different microbes examined, and this reactivity can be manipulated by orchestrating desired bacteria in water where parent fish live or immunizing the parent fish through vaccination. These observations suggest that maternal IgZ may represent a group of polyclonal Abs, providing protection against various environmental microbes encountered by a parent fish that were potentially high risk to offspring. To our knowledge, our findings provide novel insights into a previously unrecognized functional role of IgZ/IgT Ig in the maternal transfer of immunity in fish, greatly enriching current knowledge about this ancient Ig class." @default.
- W3155199462 created "2021-04-26" @default.
- W3155199462 creator A5009318195 @default.
- W3155199462 creator A5012365466 @default.
- W3155199462 creator A5035763011 @default.
- W3155199462 creator A5040388557 @default.
- W3155199462 creator A5043918375 @default.
- W3155199462 creator A5061179820 @default.
- W3155199462 creator A5063144492 @default.
- W3155199462 creator A5081065159 @default.
- W3155199462 creator A5082747056 @default.
- W3155199462 date "2021-05-01" @default.
- W3155199462 modified "2023-10-17" @default.
- W3155199462 title "New Insights into IgZ as a Maternal Transfer Ig Contributing to the Early Defense of Fish against Pathogen Infection" @default.
- W3155199462 cites W1494035906 @default.
- W3155199462 cites W1588812362 @default.
- W3155199462 cites W1600015917 @default.
- W3155199462 cites W1624522306 @default.
- W3155199462 cites W1636776819 @default.
- W3155199462 cites W1965091685 @default.
- W3155199462 cites W1970161837 @default.
- W3155199462 cites W1971902835 @default.
- W3155199462 cites W1975317363 @default.
- W3155199462 cites W1978806449 @default.
- W3155199462 cites W1979123585 @default.
- W3155199462 cites W1985560800 @default.
- W3155199462 cites W1989402989 @default.
- W3155199462 cites W1989608676 @default.
- W3155199462 cites W1990580731 @default.
- W3155199462 cites W1995986346 @default.
- W3155199462 cites W2018337150 @default.
- W3155199462 cites W2029897223 @default.
- W3155199462 cites W2032422400 @default.
- W3155199462 cites W2034087823 @default.
- W3155199462 cites W2039198578 @default.
- W3155199462 cites W2040987934 @default.
- W3155199462 cites W2045444884 @default.
- W3155199462 cites W2046683160 @default.
- W3155199462 cites W2047090987 @default.
- W3155199462 cites W2048676393 @default.
- W3155199462 cites W2054077259 @default.
- W3155199462 cites W2058740609 @default.
- W3155199462 cites W2069102932 @default.
- W3155199462 cites W2072972153 @default.
- W3155199462 cites W2082740154 @default.
- W3155199462 cites W2083575792 @default.
- W3155199462 cites W2084519012 @default.
- W3155199462 cites W2087621363 @default.
- W3155199462 cites W2089156624 @default.
- W3155199462 cites W2092348049 @default.
- W3155199462 cites W2095086266 @default.
- W3155199462 cites W2110942360 @default.
- W3155199462 cites W2112528263 @default.
- W3155199462 cites W2122635106 @default.
- W3155199462 cites W2129935560 @default.
- W3155199462 cites W2130332230 @default.
- W3155199462 cites W2144797013 @default.
- W3155199462 cites W2145380311 @default.
- W3155199462 cites W2149599151 @default.
- W3155199462 cites W2150079601 @default.
- W3155199462 cites W2154938671 @default.
- W3155199462 cites W2155366992 @default.
- W3155199462 cites W2165090944 @default.
- W3155199462 cites W2256756668 @default.
- W3155199462 cites W2297883954 @default.
- W3155199462 cites W2342004244 @default.
- W3155199462 cites W2346603537 @default.
- W3155199462 cites W2584792484 @default.
- W3155199462 cites W2597050443 @default.
- W3155199462 cites W2597511687 @default.
- W3155199462 cites W2759933576 @default.
- W3155199462 cites W2790505494 @default.
- W3155199462 cites W2949340230 @default.
- W3155199462 cites W2969370769 @default.
- W3155199462 cites W3005424996 @default.
- W3155199462 cites W3007135380 @default.
- W3155199462 cites W3015967897 @default.
- W3155199462 cites W411823555 @default.
- W3155199462 cites W826255884 @default.
- W3155199462 doi "https://doi.org/10.4049/jimmunol.2001197" @default.
- W3155199462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33858963" @default.
- W3155199462 hasPublicationYear "2021" @default.
- W3155199462 type Work @default.
- W3155199462 sameAs 3155199462 @default.
- W3155199462 citedByCount "7" @default.
- W3155199462 countsByYear W31551994622021 @default.
- W3155199462 countsByYear W31551994622022 @default.
- W3155199462 countsByYear W31551994622023 @default.
- W3155199462 crossrefType "journal-article" @default.
- W3155199462 hasAuthorship W3155199462A5009318195 @default.
- W3155199462 hasAuthorship W3155199462A5012365466 @default.
- W3155199462 hasAuthorship W3155199462A5035763011 @default.
- W3155199462 hasAuthorship W3155199462A5040388557 @default.
- W3155199462 hasAuthorship W3155199462A5043918375 @default.
- W3155199462 hasAuthorship W3155199462A5061179820 @default.
- W3155199462 hasAuthorship W3155199462A5063144492 @default.
- W3155199462 hasAuthorship W3155199462A5081065159 @default.
- W3155199462 hasAuthorship W3155199462A5082747056 @default.