FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3155205875> ?p ?o ?g. }

• W3155205875 abstract "Author(s): Zutshi, Ipshita | Advisor(s): Leutgeb, Stefan | Abstract: Memory and spatial navigation involve complex neural processes that depend on accurate and coordinated firing of neurons within the hippocampus and medial entorhinal cortex (mEC). Neurons within these regions are tuned to various features of the environment, including space and context, and incorrect firing is hypothesized to lead to catastrophic errors in our ability to generate new, stable, and coherent memories. There are numerous methods in which the brain might establish and maintain reliable firing, and here, we examined different network mechanisms that determine spike timing. The first property that significantly influences the firing of neurons is the network connectivity of cells within and between brain regions. To understand how networks are organized within the mEC, we employed rabies virus-mediated retrograde trading and determined that projections within the superficial layers of the mEC are organized as cortical columns, parallel to the radial axis of the brain. Next, with information on how these local projections are organized, we performed transient, local perturbations of these circuits and examined whether the precise spatial firing of neurons within the mEC is dependent on these local circuits. While we found small errors in the spatial firing of grid cells following each perturbation, these errors were brief and not cumulative, suggesting robust mechanisms for afferent inputs to maintain firing. In addition to the connectivity between neurons, a key factor coordinating spike timing, especially between brain regions, are global oscillations that act as an external pacemaker. Within the context of the mEC and hippocampus, these are called theta oscillations, and most neurons within these brain regions are rhythmically paced to theta oscillations. To test how these oscillations might coordinate spike timing, we artificially accelerated the frequency of theta oscillations and determined that neurons within the hippocampus respond to the stimulation by shifting their oscillation frequencies to match the stimulation frequency. Finally, we provide an example of how a functional readout of coordinated spiking between neurons involving both the above described mechanisms – a local network dependent rate code, and theta oscillation dependent temporal code – may be used on a population level to generate complex internal representations." @default.
• W3155205875 created "2021-04-26" @default.
• W3155205875 creator A5006327764 @default.
• W3155205875 date "2019-01-01" @default.
• W3155205875 modified "2023-09-27" @default.
• W3155205875 title "Dissecting Circuits that Coordinate Spike Timing in the Hippocampus and Medial Entorhinal Cortex" @default.
• W3155205875 hasPublicationYear "2019" @default.
• W3155205875 type Work @default.
• W3155205875 sameAs 3155205875 @default.
• W3155205875 citedByCount "0" @default.
• W3155205875 crossrefType "journal-article" @default.
• W3155205875 hasAuthorship W3155205875A5006327764 @default.
• W3155205875 hasConcept C115903868 @default.
• W3155205875 hasConcept C118403218 @default.
• W3155205875 hasConcept C151730666 @default.
• W3155205875 hasConcept C169760540 @default.
• W3155205875 hasConcept C2779343474 @default.
• W3155205875 hasConcept C2780196419 @default.
• W3155205875 hasConcept C2780715579 @default.
• W3155205875 hasConcept C2781161787 @default.
• W3155205875 hasConcept C2781390188 @default.
• W3155205875 hasConcept C3018011982 @default.
• W3155205875 hasConcept C41008148 @default.
• W3155205875 hasConcept C45715564 @default.
• W3155205875 hasConcept C86803240 @default.
• W3155205875 hasConceptScore W3155205875C115903868 @default.
• W3155205875 hasConceptScore W3155205875C118403218 @default.
• W3155205875 hasConceptScore W3155205875C151730666 @default.
• W3155205875 hasConceptScore W3155205875C169760540 @default.
• W3155205875 hasConceptScore W3155205875C2779343474 @default.
• W3155205875 hasConceptScore W3155205875C2780196419 @default.
• W3155205875 hasConceptScore W3155205875C2780715579 @default.
• W3155205875 hasConceptScore W3155205875C2781161787 @default.
• W3155205875 hasConceptScore W3155205875C2781390188 @default.
• W3155205875 hasConceptScore W3155205875C3018011982 @default.
• W3155205875 hasConceptScore W3155205875C41008148 @default.
• W3155205875 hasConceptScore W3155205875C45715564 @default.
• W3155205875 hasConceptScore W3155205875C86803240 @default.
• W3155205875 hasLocation W31552058751 @default.
• W3155205875 hasOpenAccess W3155205875 @default.
• W3155205875 hasPrimaryLocation W31552058751 @default.
• W3155205875 hasRelatedWork W125207487 @default.
• W3155205875 hasRelatedWork W131540589 @default.
• W3155205875 hasRelatedWork W151088228 @default.
• W3155205875 hasRelatedWork W1577239607 @default.
• W3155205875 hasRelatedWork W1992163286 @default.
• W3155205875 hasRelatedWork W2014699235 @default.
• W3155205875 hasRelatedWork W2017732512 @default.
• W3155205875 hasRelatedWork W2037114765 @default.
• W3155205875 hasRelatedWork W2038034693 @default.
• W3155205875 hasRelatedWork W2045308183 @default.
• W3155205875 hasRelatedWork W2049979618 @default.
• W3155205875 hasRelatedWork W2066269536 @default.
• W3155205875 hasRelatedWork W2100180272 @default.
• W3155205875 hasRelatedWork W2153108599 @default.
• W3155205875 hasRelatedWork W2237465850 @default.
• W3155205875 hasRelatedWork W2429698163 @default.
• W3155205875 hasRelatedWork W2522437752 @default.
• W3155205875 hasRelatedWork W2531263448 @default.
• W3155205875 hasRelatedWork W2606374590 @default.
• W3155205875 hasRelatedWork W3009535184 @default.
• W3155205875 isParatext "false" @default.
• W3155205875 isRetracted "false" @default.
• W3155205875 magId "3155205875" @default.
• W3155205875 workType "article" @default.