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- W3155247946 abstract "Activating mutations in the ras proto-oncogene lead to increased,unregulated cellular proliferation. Point mutations in ras codons 12and 13 are early events in 40-50% of colorectal cancer cases, and areassociated with shortened patient survival. Procedures for mutationdetection, which are used in patient diagnostic evaluation, have beendeveloped for various populations, but not for Filipinos. This study aimsto determine the incidence of ras mutations among Filipino colorectalcancer and non-cancer patients and to evaluate the usefulness of ras mutation detection in colorectal cancer diagnostics. Two rapid, costeffective mutation detection methods are also evaluated. Restrictionfragment length polymorphism (RFLP) detects mutations in codons12 and 13 while single strand conformational polymorphism (SSCP)detects any mutation in the amplicons screened. PCR-amplifiedras exon 1 from 21 colorectal cancer and 17 non-cancerous tissuesamples were analyzed. DNA sequencing confirmed the presence of sixsubstitution mutations: five (23.8%) in cancer samples and one (5.9%)in a non-cancer sample. RFLP detected all mutations, while SSCP failedto detect one, suggesting that RFLP is the better method for mutationscreening. The incidence of ras mutations among Filipino colorectalcancer patients is lower than in other populations, suggesting that ras mutation detection is a highly sensitive but not specific diagnostic toolfor colorectal cancer in Filipinos." @default.
- W3155247946 created "2021-04-26" @default.
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- W3155247946 date "2008-12-04" @default.
- W3155247946 modified "2023-09-24" @default.
- W3155247946 title "Evaluation of ras Mutations in Filipino Colorectal Patients" @default.
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- W3155247946 doi "https://doi.org/10.47895/amp.v42i2.2425" @default.
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