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- W3155253185 startingPage "377" @default.
- W3155253185 abstract "Inflammation can occur in response to transient or chronic conditions. Transient inflammation is beneficial during injury or invasion of pathogens. Chronic inflammation presents an unresolved response which can have harmful consequences to the host system. Inflammation is prevalent in multiple human diseases. Current studies provide a strong association between inflammation and cancer. Mitochondrial dysfunction augments the production of mitochondrial reactive oxygen species (mtROS) to support inflammation and proliferation via release of various cytokines. Inflammation, in turn, can further induce mitochondrial dysfunction and reactive oxygen species (ROS) to create a feedback loop of inflammatory insult, which supports the growth and survival of tumor cells. Current pharmacological agents seek to exploit this process by targeting either the mitochondria or downstream targets of the mitochondria which promote inflammation. This chapter delves into the origins of mitochondrial dysfunction and the corresponding signaling pathways that regulate inflammation in cancer." @default.
- W3155253185 created "2021-04-26" @default.
- W3155253185 creator A5012219857 @default.
- W3155253185 creator A5033228095 @default.
- W3155253185 creator A5055933008 @default.
- W3155253185 creator A5063116970 @default.
- W3155253185 date "2021-01-01" @default.
- W3155253185 modified "2023-10-14" @default.
- W3155253185 title "Mitochondrial Regulation of Inflammation in Cancer" @default.
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