Matches in SemOpenAlex for { <https://semopenalex.org/work/W3155255157> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W3155255157 abstract "Abstract Background: Membranous nephropathy (MN) and minimal change disease (MCD) are two common causes leading to nephrotic syndrome (NS). They have similar clinical feature but different treatment strategy and prognosis. M-type phospholipase A2 receptor (PLA2R) is considered as a specific marker of membranous nephropathy. However, its sensitivity is only about 70%. Therefore, there is a lack of effective and noninvasive tools to distinguish PLA2R-negative MN and MCD patients without renal biopsy. We aim to develop a discrimination model using noninvasive parameters for distinguishing the two diseases and support immediate treatment before result of renal biopsy. Methods: A total 949 patients who were pathologically diagnosed as idiopathic MN or primary MCD in the First Affiliated Hospital of Zhengzhou University from January 2017 to August 2019 were enrolled in this study, including 805 idiopathic MN (605 PLAR2-positive MN and 200 PLA2R-negative MN) and 144 primary MCD. Based on the basic information and laboratory examination of 200 PLA2R-negative MN and 144 MCD, we used a univariate and multivariate logistic regression to select the relevant variables and develop the discrimination model. ROC curve and calibration curve were used to evaluate the diagnostic ability and calibration ability of the model. The decision curve was used to calculate the net benefit. We also test the effectiveness of our model in all 949 patients. Results: A novel model that included age, albumin, urea, high density lipoprotein, urea and red blood cell count was established for PLA2R-negative MN and MCD. The discrimination model has excellent differential capability (an AUC of 0.889 in training group and an AUC of 0.920 in test group) and calibration capability. When testing in all 949 patients, our model also showed good discrimination ability for all idiopathic MN and MCD. Conclusion: We constructed a discrimination model with high diagnostic effectiveness for PLA2R-negative MN and MCD. The model could also be used for all idiopathic MN and MCD patients." @default.
- W3155255157 created "2021-04-26" @default.
- W3155255157 creator A5013712705 @default.
- W3155255157 creator A5016689945 @default.
- W3155255157 creator A5017970376 @default.
- W3155255157 creator A5033437595 @default.
- W3155255157 creator A5037833839 @default.
- W3155255157 creator A5044501118 @default.
- W3155255157 creator A5048099376 @default.
- W3155255157 creator A5049937552 @default.
- W3155255157 creator A5067881411 @default.
- W3155255157 creator A5076950139 @default.
- W3155255157 creator A5080907045 @default.
- W3155255157 creator A5081085562 @default.
- W3155255157 date "2021-04-15" @default.
- W3155255157 modified "2023-10-16" @default.
- W3155255157 title "Development and Validation of a Between Primary PLA2R-Negative Membranous Nephropathy and Minimal Change Disease Confirmed by Renal Biopsy" @default.
- W3155255157 doi "https://doi.org/10.21203/rs.3.rs-410190/v1" @default.
- W3155255157 hasPublicationYear "2021" @default.
- W3155255157 type Work @default.
- W3155255157 sameAs 3155255157 @default.
- W3155255157 citedByCount "0" @default.
- W3155255157 crossrefType "posted-content" @default.
- W3155255157 hasAuthorship W3155255157A5013712705 @default.
- W3155255157 hasAuthorship W3155255157A5016689945 @default.
- W3155255157 hasAuthorship W3155255157A5017970376 @default.
- W3155255157 hasAuthorship W3155255157A5033437595 @default.
- W3155255157 hasAuthorship W3155255157A5037833839 @default.
- W3155255157 hasAuthorship W3155255157A5044501118 @default.
- W3155255157 hasAuthorship W3155255157A5048099376 @default.
- W3155255157 hasAuthorship W3155255157A5049937552 @default.
- W3155255157 hasAuthorship W3155255157A5067881411 @default.
- W3155255157 hasAuthorship W3155255157A5076950139 @default.
- W3155255157 hasAuthorship W3155255157A5080907045 @default.
- W3155255157 hasAuthorship W3155255157A5081085562 @default.
- W3155255157 hasBestOaLocation W31552551571 @default.
- W3155255157 hasConcept C126322002 @default.
- W3155255157 hasConcept C142724271 @default.
- W3155255157 hasConcept C151956035 @default.
- W3155255157 hasConcept C2775934546 @default.
- W3155255157 hasConcept C2775946357 @default.
- W3155255157 hasConcept C2777747828 @default.
- W3155255157 hasConcept C2778415529 @default.
- W3155255157 hasConcept C2778930706 @default.
- W3155255157 hasConcept C2779561371 @default.
- W3155255157 hasConcept C2780091579 @default.
- W3155255157 hasConcept C2781087799 @default.
- W3155255157 hasConcept C71924100 @default.
- W3155255157 hasConcept C90924648 @default.
- W3155255157 hasConceptScore W3155255157C126322002 @default.
- W3155255157 hasConceptScore W3155255157C142724271 @default.
- W3155255157 hasConceptScore W3155255157C151956035 @default.
- W3155255157 hasConceptScore W3155255157C2775934546 @default.
- W3155255157 hasConceptScore W3155255157C2775946357 @default.
- W3155255157 hasConceptScore W3155255157C2777747828 @default.
- W3155255157 hasConceptScore W3155255157C2778415529 @default.
- W3155255157 hasConceptScore W3155255157C2778930706 @default.
- W3155255157 hasConceptScore W3155255157C2779561371 @default.
- W3155255157 hasConceptScore W3155255157C2780091579 @default.
- W3155255157 hasConceptScore W3155255157C2781087799 @default.
- W3155255157 hasConceptScore W3155255157C71924100 @default.
- W3155255157 hasConceptScore W3155255157C90924648 @default.
- W3155255157 hasLocation W31552551571 @default.
- W3155255157 hasOpenAccess W3155255157 @default.
- W3155255157 hasPrimaryLocation W31552551571 @default.
- W3155255157 hasRelatedWork W1939640568 @default.
- W3155255157 hasRelatedWork W2042172609 @default.
- W3155255157 hasRelatedWork W2255097837 @default.
- W3155255157 hasRelatedWork W2483763608 @default.
- W3155255157 hasRelatedWork W2501089221 @default.
- W3155255157 hasRelatedWork W2605720291 @default.
- W3155255157 hasRelatedWork W2807081212 @default.
- W3155255157 hasRelatedWork W3169043963 @default.
- W3155255157 hasRelatedWork W4236343510 @default.
- W3155255157 hasRelatedWork W4300513650 @default.
- W3155255157 isParatext "false" @default.
- W3155255157 isRetracted "false" @default.
- W3155255157 magId "3155255157" @default.
- W3155255157 workType "article" @default.