FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3155264313> ?p ?o ?g. }

• W3155264313 abstract "Metabolically engineered cyanobacteria have the potential to mitigate anthropogenic CO 2 emissions by converting CO 2 into renewable fuels and chemicals. Yet, better understanding of metabolic regulation in cyanobacteria is required to develop more productive strains that can make industrial scale-up economically feasible. The aim of this study was to find the cause for the previously reported inconsistency between oscillating transcription and constant protein levels under day-night growth conditions. To determine whether translational regulation counteracts transcriptional changes, Synechocystis sp. PCC 6803 was cultivated in an artificial day-night setting and the level of transcription, translation and protein was measured across the genome at different time points using mRNA sequencing, ribosome profiling and quantitative proteomics. Furthermore, the effect of protein turnover on the amplitude of protein oscillations was investigated through in silico simulations using a protein mass balance model. Our experimental analysis revealed that protein oscillations were not dampened by translational regulation, as evidenced by high correlation between translational and transcriptional oscillations ( r = 0.88) and unchanged protein levels. Instead, model simulations showed that these observations can be attributed to a slow protein turnover, which reduces the effect of protein synthesis oscillations on the protein level. In conclusion, these results suggest that cyanobacteria have evolved to govern diurnal metabolic shifts through allosteric regulatory mechanisms in order to avoid the energy burden of replacing the proteome on a daily basis. Identification and manipulation of such mechanisms could be part of a metabolic engineering strategy for overproduction of chemicals." @default.
• W3155264313 created "2021-04-26" @default.
• W3155264313 creator A5020486141 @default.
• W3155264313 creator A5027625454 @default.
• W3155264313 creator A5036268179 @default.
• W3155264313 creator A5060766502 @default.
• W3155264313 creator A5083242474 @default.
• W3155264313 date "2021-04-14" @default.
• W3155264313 modified "2023-10-17" @default.
• W3155264313 title "Slow Protein Turnover Explains Limited Protein-Level Response to Diurnal Transcriptional Oscillations in Cyanobacteria" @default.
• W3155264313 cites W1549011594 @default.
• W3155264313 cites W1976761763 @default.
• W3155264313 cites W1987511012 @default.
• W3155264313 cites W1988096147 @default.
• W3155264313 cites W1991123854 @default.
• W3155264313 cites W1996230229 @default.
• W3155264313 cites W2005288984 @default.
• W3155264313 cites W2019050932 @default.
• W3155264313 cites W2020340169 @default.
• W3155264313 cites W2036897871 @default.
• W3155264313 cites W2042315785 @default.
• W3155264313 cites W2051342143 @default.
• W3155264313 cites W2052593484 @default.
• W3155264313 cites W2054492925 @default.
• W3155264313 cites W2083116560 @default.
• W3155264313 cites W2109281577 @default.
• W3155264313 cites W2124985265 @default.
• W3155264313 cites W2127256752 @default.
• W3155264313 cites W2129975375 @default.
• W3155264313 cites W2138720394 @default.
• W3155264313 cites W2148042832 @default.
• W3155264313 cites W2175136759 @default.
• W3155264313 cites W2269415044 @default.
• W3155264313 cites W2345452747 @default.
• W3155264313 cites W2464114205 @default.
• W3155264313 cites W2489579440 @default.
• W3155264313 cites W2510334816 @default.
• W3155264313 cites W2582331638 @default.
• W3155264313 cites W2586644082 @default.
• W3155264313 cites W2606147900 @default.
• W3155264313 cites W2617949040 @default.
• W3155264313 cites W2724889495 @default.
• W3155264313 cites W2736780095 @default.
• W3155264313 cites W2790932896 @default.
• W3155264313 cites W2795003040 @default.
• W3155264313 cites W2896654920 @default.
• W3155264313 cites W2896764488 @default.
• W3155264313 cites W2904210961 @default.
• W3155264313 cites W2909958885 @default.
• W3155264313 cites W2923185669 @default.
• W3155264313 cites W2962101943 @default.
• W3155264313 cites W3010630503 @default.
• W3155264313 doi "https://doi.org/10.3389/fmicb.2021.657379" @default.
• W3155264313 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8237939" @default.
• W3155264313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34194405" @default.
• W3155264313 hasPublicationYear "2021" @default.
• W3155264313 type Work @default.
• W3155264313 sameAs 3155264313 @default.
• W3155264313 citedByCount "11" @default.
• W3155264313 countsByYear W31552643132021 @default.
• W3155264313 countsByYear W31552643132022 @default.
• W3155264313 countsByYear W31552643132023 @default.
• W3155264313 crossrefType "journal-article" @default.
• W3155264313 hasAuthorship W3155264313A5020486141 @default.
• W3155264313 hasAuthorship W3155264313A5027625454 @default.
• W3155264313 hasAuthorship W3155264313A5036268179 @default.
• W3155264313 hasAuthorship W3155264313A5060766502 @default.
• W3155264313 hasAuthorship W3155264313A5083242474 @default.
• W3155264313 hasBestOaLocation W31552643131 @default.
• W3155264313 hasConcept C104317684 @default.
• W3155264313 hasConcept C104397665 @default.
• W3155264313 hasConcept C105580179 @default.
• W3155264313 hasConcept C12554922 @default.
• W3155264313 hasConcept C149364088 @default.
• W3155264313 hasConcept C195580219 @default.
• W3155264313 hasConcept C27153228 @default.
• W3155264313 hasConcept C2775905019 @default.
• W3155264313 hasConcept C2779669040 @default.
• W3155264313 hasConcept C3675279 @default.
• W3155264313 hasConcept C39685955 @default.
• W3155264313 hasConcept C46111723 @default.
• W3155264313 hasConcept C523546767 @default.
• W3155264313 hasConcept C54355233 @default.
• W3155264313 hasConcept C55493867 @default.
• W3155264313 hasConcept C70721500 @default.
• W3155264313 hasConcept C80311884 @default.
• W3155264313 hasConcept C86339819 @default.
• W3155264313 hasConcept C86803240 @default.
• W3155264313 hasConcept C95444343 @default.
• W3155264313 hasConceptScore W3155264313C104317684 @default.
• W3155264313 hasConceptScore W3155264313C104397665 @default.
• W3155264313 hasConceptScore W3155264313C105580179 @default.
• W3155264313 hasConceptScore W3155264313C12554922 @default.
• W3155264313 hasConceptScore W3155264313C149364088 @default.
• W3155264313 hasConceptScore W3155264313C195580219 @default.
• W3155264313 hasConceptScore W3155264313C27153228 @default.
• W3155264313 hasConceptScore W3155264313C2775905019 @default.
• W3155264313 hasConceptScore W3155264313C2779669040 @default.
• W3155264313 hasConceptScore W3155264313C3675279 @default.
• W3155264313 hasConceptScore W3155264313C39685955 @default.

• next