Matches in SemOpenAlex for { <https://semopenalex.org/work/W3155339504> ?p ?o ?g. }
- W3155339504 endingPage "1209" @default.
- W3155339504 startingPage "1196" @default.
- W3155339504 abstract "Polymerase δ-interacting protein 2 (POLDIP2, PDIP38) is a multifaceted, moonlighting protein, involved in binding protein partners from many different cellular processes, including mitochondrial metabolism and DNA replication and repair. How POLDIP2 interacts with many different proteins is unknown. Towards this goal, we present the crystal structure of POLDIP2 to 2.8 Å, which exhibited a compact two-domain β-strand-rich globular structure, confirmed by circular dichroism and small angle X-ray scattering approaches. POLDIP2 comprised canonical DUF525 and YccV domains, but with a conserved domain linker packed tightly, resulting in an extended YccV module. A central channel was observed, which we hypothesize could influence structural changes potentially mediated by redox conditions, following observation of a modified cysteine residue in the channel. Unstructured regions were rebuilt by ab initio modelling to generate a model of full-length POLDIP2. Molecular dynamics simulations revealed a highly dynamic N-terminal region tethered to the YccV-domain by an extended linker, potentially facilitating interactions with distal binding partners. Models of POLDIP2 complexed with two of its partners, PrimPol and PCNA, indicated that dynamic flexibility of the POLDIP2 N-terminus and loop regions likely mediate protein interactions." @default.
- W3155339504 created "2021-04-26" @default.
- W3155339504 creator A5024062505 @default.
- W3155339504 creator A5044603983 @default.
- W3155339504 creator A5044806743 @default.
- W3155339504 creator A5060479920 @default.
- W3155339504 creator A5072524643 @default.
- W3155339504 creator A5084407097 @default.
- W3155339504 creator A5090971727 @default.
- W3155339504 date "2021-05-10" @default.
- W3155339504 modified "2023-10-10" @default.
- W3155339504 title "Crystal structure and molecular dynamics of human <scp>POLDIP2</scp> , a multifaceted adaptor protein in metabolism and genome stability" @default.
- W3155339504 cites W1975304761 @default.
- W3155339504 cites W1983016535 @default.
- W3155339504 cites W1986633155 @default.
- W3155339504 cites W2003889822 @default.
- W3155339504 cites W2008000048 @default.
- W3155339504 cites W2015115860 @default.
- W3155339504 cites W2025410059 @default.
- W3155339504 cites W2030760648 @default.
- W3155339504 cites W2035503835 @default.
- W3155339504 cites W2050331566 @default.
- W3155339504 cites W2055043387 @default.
- W3155339504 cites W2069738960 @default.
- W3155339504 cites W2073144162 @default.
- W3155339504 cites W2074986801 @default.
- W3155339504 cites W2095036253 @default.
- W3155339504 cites W2105762966 @default.
- W3155339504 cites W2108921801 @default.
- W3155339504 cites W2118193478 @default.
- W3155339504 cites W2124026197 @default.
- W3155339504 cites W2140260269 @default.
- W3155339504 cites W2143815085 @default.
- W3155339504 cites W2148698435 @default.
- W3155339504 cites W2154319440 @default.
- W3155339504 cites W2159957100 @default.
- W3155339504 cites W2160378127 @default.
- W3155339504 cites W2160544821 @default.
- W3155339504 cites W2163341755 @default.
- W3155339504 cites W2169615650 @default.
- W3155339504 cites W2170146374 @default.
- W3155339504 cites W2170408275 @default.
- W3155339504 cites W2310339811 @default.
- W3155339504 cites W2332459948 @default.
- W3155339504 cites W2376573086 @default.
- W3155339504 cites W2537276668 @default.
- W3155339504 cites W2620067343 @default.
- W3155339504 cites W2620611095 @default.
- W3155339504 cites W2707646777 @default.
- W3155339504 cites W2731784911 @default.
- W3155339504 cites W2765515902 @default.
- W3155339504 cites W2799409314 @default.
- W3155339504 cites W2884841745 @default.
- W3155339504 cites W2898521489 @default.
- W3155339504 cites W2903955117 @default.
- W3155339504 cites W2912126500 @default.
- W3155339504 cites W2946957646 @default.
- W3155339504 cites W2977366709 @default.
- W3155339504 cites W3021399002 @default.
- W3155339504 cites W3021551525 @default.
- W3155339504 cites W3093373024 @default.
- W3155339504 cites W3097069203 @default.
- W3155339504 cites W3126403906 @default.
- W3155339504 cites W4210675630 @default.
- W3155339504 cites W4256605058 @default.
- W3155339504 doi "https://doi.org/10.1002/pro.4085" @default.
- W3155339504 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8138528" @default.
- W3155339504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33884680" @default.
- W3155339504 hasPublicationYear "2021" @default.
- W3155339504 type Work @default.
- W3155339504 sameAs 3155339504 @default.
- W3155339504 citedByCount "5" @default.
- W3155339504 countsByYear W31553395042022 @default.
- W3155339504 countsByYear W31553395042023 @default.
- W3155339504 crossrefType "journal-article" @default.
- W3155339504 hasAuthorship W3155339504A5024062505 @default.
- W3155339504 hasAuthorship W3155339504A5044603983 @default.
- W3155339504 hasAuthorship W3155339504A5044806743 @default.
- W3155339504 hasAuthorship W3155339504A5060479920 @default.
- W3155339504 hasAuthorship W3155339504A5072524643 @default.
- W3155339504 hasAuthorship W3155339504A5084407097 @default.
- W3155339504 hasAuthorship W3155339504A5090971727 @default.
- W3155339504 hasBestOaLocation W31553395041 @default.
- W3155339504 hasConcept C111919701 @default.
- W3155339504 hasConcept C12554922 @default.
- W3155339504 hasConcept C147597530 @default.
- W3155339504 hasConcept C153064111 @default.
- W3155339504 hasConcept C178790620 @default.
- W3155339504 hasConcept C185592680 @default.
- W3155339504 hasConcept C203036418 @default.
- W3155339504 hasConcept C2780557392 @default.
- W3155339504 hasConcept C41008148 @default.
- W3155339504 hasConcept C47701112 @default.
- W3155339504 hasConcept C55493867 @default.
- W3155339504 hasConcept C59593255 @default.
- W3155339504 hasConcept C8010536 @default.
- W3155339504 hasConcept C86803240 @default.
- W3155339504 hasConceptScore W3155339504C111919701 @default.