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• W3155377581 abstract "Background. Central diabetes insipidus is characte­rized by the inability of the kidneys to reabsorb water and concentrate urine, which is due to the defect in the synthesis or secretion of vasopressin and is manifested by severe thirst and excretion of large amounts of diluted urine. The purpose of the study is to assess the prevalence of various forms of diabetes insipidus and its complications, the quality of diagnosis and treatment according to the data of regional endocrinological dispensaries of the Republic of Uzbekistan. Materials and methods. The study used data from the register of patients with diabetes insipidus registered in regional endocrinological centers in all regions of the Republic of Uzbekistan and the Republic of Karakalpakstan in 2018, as well as our own observations. It was found that by the end of 2018, 1,237 children and adolescents with diabetes insipidus were registered in the Republic of Uzbekistan and the Republic of Karakalpakstan. Of these, data of 397 patients with diabetes insipidus were analyzed. Their average age was 5.6 ± 2 years. Results. The idiopathic form of diabetes insipidus was observed predominantly — in 214 individuals (55.8 %), the second most common form was central diabetes insipidus — 129 patients (40.9 %), while the renal and hereditary forms of the disease were less common — 26 (3.3 %) and 3 (0.2 %), respectively. The majority of patients (48.9 %) did not associate the onset of the disease with any factor. However, in 20.4 % of individuals, diabetes insipidus developed after a skull injury. In 4.8 % of patients, the cause of the disease was tumors of the hypothalamic-pituitary region, and in 14.5 % — neuroviral infection. Hereditary predisposition was observed in 0.4 % of patients. Conclusions. In the regions of the Republic of Uzbekistan and the Republic of Karakalpakstan, two forms of diabetes insipidus were most common: idiopathic — 214 (55.8 %) and central — 129 cases (40.9 %). Most of the patients — 85 children (22.9%) — were aged 0 to 9 years. The average age of ill children and adolescents was 7.6 years. The disease was more often detected in males (51.1 %)." @default.
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• W3155377581 date "2021-04-06" @default.
• W3155377581 modified "2023-09-25" @default.
• W3155377581 title "Prevalence of various forms of diabetes insipidus and its complications in the Republic of Uzbekistan" @default.
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• W3155377581 doi "https://doi.org/10.22141/2224-0721.16.8.2020.222891" @default.
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