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- W3155383858 endingPage "4429" @default.
- W3155383858 startingPage "4410" @default.
- W3155383858 abstract "The World Health Organization assigns international nonproprietary names (INN), also known as common names, to compounds upon request from drug developers. Structures of INNs are publicly available and represent a source, albeit underused, to understand trends in drug research and development. Here, we explain how a common drug name is composed and analyze chemical entities from 2000 to 2021. In the analysis, we describe some changes that intertwine chemical structure, newer therapeutic targets (e.g., kinases), including a significant increase in the use of fluorine and of heterocycles, and some other evolutionary modifications, such as the progressive increase in molecular weight. Alongside these, small signs of change can be spotted, such as the rise in spirocyclic scaffolds and small rings and the emergence of unconventional structural moieties that might forecast the future to come." @default.
- W3155383858 created "2021-04-26" @default.
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- W3155383858 creator A5090528914 @default.
- W3155383858 date "2021-04-13" @default.
- W3155383858 modified "2023-10-15" @default.
- W3155383858 title "What’s in a Name? Drug Nomenclature and Medicinal Chemistry Trends using INN Publications" @default.
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- W3155383858 doi "https://doi.org/10.1021/acs.jmedchem.1c00181" @default.
- W3155383858 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8154580" @default.
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- W3155383858 hasPublicationYear "2021" @default.
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