Matches in SemOpenAlex for { <https://semopenalex.org/work/W3155403497> ?p ?o ?g. }
- W3155403497 endingPage "916" @default.
- W3155403497 startingPage "916" @default.
- W3155403497 abstract "Coronavirus disease 2019 (COVID-19) is the most devastating infectious disease in the 21st century with more than 2 million lives lost in less than a year. The activation of inflammasome in the host infected by SARS-CoV-2 is highly related to cytokine storm and hypercoagulopathy, which significantly contribute to the poor prognosis of COVID-19 patients. Even though many studies have shown the host defense mechanism induced by inflammasome against various viral infections, mechanistic interactions leading to downstream cellular responses and pathogenesis in COVID-19 remain unclear. The SARS-CoV-2 infection has been associated with numerous cardiovascular disorders including acute myocardial injury, myocarditis, arrhythmias, and venous thromboembolism. The inflammatory response triggered by the activation of NLRP3 inflammasome under certain cardiovascular conditions resulted in hyperinflammation or the modulation of angiotensin-converting enzyme 2 signaling pathways. Perturbations of several target cells and tissues have been described in inflammasome activation, including pneumocytes, macrophages, endothelial cells, and dendritic cells. The interplay between inflammasome activation and hypercoagulopathy in COVID-19 patients is an emerging area to be further addressed. Targeted therapeutics to suppress inflammasome activation may have a positive effect on the reduction of hyperinflammation-induced hypercoagulopathy and cardiovascular disorders occurring as COVID-19 complications." @default.
- W3155403497 created "2021-04-26" @default.
- W3155403497 creator A5005441246 @default.
- W3155403497 creator A5047068233 @default.
- W3155403497 creator A5061933027 @default.
- W3155403497 creator A5062033583 @default.
- W3155403497 creator A5079835727 @default.
- W3155403497 creator A5082692871 @default.
- W3155403497 date "2021-04-16" @default.
- W3155403497 modified "2023-09-29" @default.
- W3155403497 title "Inflammasome Activation-Induced Hypercoagulopathy: Impact on Cardiovascular Dysfunction Triggered in COVID-19 Patients" @default.
- W3155403497 cites W1561041814 @default.
- W3155403497 cites W1743744546 @default.
- W3155403497 cites W1825604636 @default.
- W3155403497 cites W1886716828 @default.
- W3155403497 cites W1900592574 @default.
- W3155403497 cites W1916325998 @default.
- W3155403497 cites W1925096404 @default.
- W3155403497 cites W1971722198 @default.
- W3155403497 cites W1972483153 @default.
- W3155403497 cites W1979838917 @default.
- W3155403497 cites W1989528047 @default.
- W3155403497 cites W1990652288 @default.
- W3155403497 cites W1996507370 @default.
- W3155403497 cites W2005359428 @default.
- W3155403497 cites W2009800174 @default.
- W3155403497 cites W2012927900 @default.
- W3155403497 cites W2024690705 @default.
- W3155403497 cites W2027502669 @default.
- W3155403497 cites W2029393588 @default.
- W3155403497 cites W2031759320 @default.
- W3155403497 cites W2036632357 @default.
- W3155403497 cites W2049203104 @default.
- W3155403497 cites W2061846412 @default.
- W3155403497 cites W2062077711 @default.
- W3155403497 cites W2065470651 @default.
- W3155403497 cites W2075529906 @default.
- W3155403497 cites W2082400315 @default.
- W3155403497 cites W2084983272 @default.
- W3155403497 cites W2091564585 @default.
- W3155403497 cites W2096626379 @default.
- W3155403497 cites W2104195963 @default.
- W3155403497 cites W2107898605 @default.
- W3155403497 cites W2122297353 @default.
- W3155403497 cites W2144467901 @default.
- W3155403497 cites W2159995809 @default.
- W3155403497 cites W2170963650 @default.
- W3155403497 cites W2172162633 @default.
- W3155403497 cites W2178413825 @default.
- W3155403497 cites W2257734931 @default.
- W3155403497 cites W2268958665 @default.
- W3155403497 cites W2410721293 @default.
- W3155403497 cites W2460178156 @default.
- W3155403497 cites W2577038661 @default.
- W3155403497 cites W2588669073 @default.
- W3155403497 cites W2593395110 @default.
- W3155403497 cites W2605773822 @default.
- W3155403497 cites W2606547287 @default.
- W3155403497 cites W2619173475 @default.
- W3155403497 cites W2623847043 @default.
- W3155403497 cites W2750878813 @default.
- W3155403497 cites W2789997601 @default.
- W3155403497 cites W2791529560 @default.
- W3155403497 cites W2791950390 @default.
- W3155403497 cites W2799466608 @default.
- W3155403497 cites W2800723006 @default.
- W3155403497 cites W2803294153 @default.
- W3155403497 cites W2804371153 @default.
- W3155403497 cites W2808838098 @default.
- W3155403497 cites W2888810697 @default.
- W3155403497 cites W2889908918 @default.
- W3155403497 cites W2898917077 @default.
- W3155403497 cites W2905245228 @default.
- W3155403497 cites W2913109339 @default.
- W3155403497 cites W2923199598 @default.
- W3155403497 cites W2941390044 @default.
- W3155403497 cites W2944725083 @default.
- W3155403497 cites W2948824749 @default.
- W3155403497 cites W2962334969 @default.
- W3155403497 cites W2963534401 @default.
- W3155403497 cites W2989755687 @default.
- W3155403497 cites W3006528168 @default.
- W3155403497 cites W3006998660 @default.
- W3155403497 cites W3007268848 @default.
- W3155403497 cites W3008461878 @default.
- W3155403497 cites W3009365815 @default.
- W3155403497 cites W3009859788 @default.
- W3155403497 cites W3009976289 @default.
- W3155403497 cites W3011268069 @default.
- W3155403497 cites W3012290165 @default.
- W3155403497 cites W3012696170 @default.
- W3155403497 cites W3014281460 @default.
- W3155403497 cites W3015549620 @default.
- W3155403497 cites W3015731395 @default.
- W3155403497 cites W3015863623 @default.
- W3155403497 cites W3016127017 @default.
- W3155403497 cites W3016326895 @default.
- W3155403497 cites W3016965546 @default.